PT  - JOURNAL ARTICLE
AU  - Westberg, Lars
AU  - Henningsson, Susanne
AU  - Landén, Mikael
AU  - Annerbrink, Kristina
AU  - Melke, Jonas
AU  - Nilsson, Staffan
AU  - Rosmond, Roland
AU  - Holm, Göran
AU  - Anckarsäter, Henrik
AU  - Eriksson, Elias
TI  - Influence of androgen receptor repeat polymorphisms on personality traits in men
DP  - 2009 May 01
TA  - Journal of Psychiatry and Neuroscience
PG  - 205--213
VI  - 34
IP  - 3
4099  - http://jpn.ca/content/34/3/205.short
4100  - http://jpn.ca/content/34/3/205.full
SO  - JPN2009 May 01; 34
AB  - Background: Testosterone has been attributed importance for various aspects of behaviour. The aim of our study was to investigate the potential influence of 2 functional polymorphisms in the amino terminal of the androgen receptor on personality traits in men.Methods: We assessed and genotyped 141 men born in 1944 recruited from the general population. We used 2 different instruments: the Karolinska Scales of Personality and the Temperament and Character Inventory. For replication, we similarly assessed 63 men recruited from a forensic psychiatry study group.Results: In the population-recruited sample, the lengths of the androgen receptor repeats were associated with neuroticism, extraversion and self-transcendence. The association with extraversion was replicated in the independent sample.Limitations: Our 2 samples differed in size; sample 1 was of moderate size and sample 2 was small. In addition, the homogeneity of sample 1 probably enhanced our ability to detect significant associations between genotype and phenotype.Conclusion: Our results suggest that the repeat polymorphisms in the androgen receptor gene may influence personality traits in men.