RT Journal Article
SR Electronic
T1 Functional neural correlates of emotional expression processing deficits in behavioural variant frontotemporal dementia
JF Journal of Psychiatry and Neuroscience
JO J Psychiatry Neurosci
FD Canadian Medical Association
SP 174
OP 182
DO 10.1503/jpn.120008
VO 38
IS 3
A1 Virani, Karim
A1 Jesso, Sarah
A1 Kertesz, Andrew
A1 Mitchell, Derek
A1 Finger, Elizabeth
YR 2013
UL http://jpn.ca/content/38/3/174.abstract
AB Background: Frontotemporal dementia (FTD) is a neurodegenerative disorder resulting in social-cognitive deficits partially attributed to abnormalities processing social cues, such as facial expressions. However, to our knowledge, the functional neuroanatomy of deficient social cue processing in individuals with FTD has not been examined. The objective of this study was to delineate the functional abnormalities underlying altered facial expression processing in individuals with FTD using functional magnetic resonance imaging (fMRI).Methods: Patients meeting Neary criteria for behavioural variant FTD (bvFTD) with supportive neuroimaging and 18 age-matched healthy controls completed an implicit facial expression task during fMRI. We conducted volumetric brain morphometry to correct functional imaging data for volume differences.Results: We included 20 patients with bvFTD and 18 controls in our study. The results demonstrate emotion-specific functional abnormalities in frontal and limbic regions in patients with bvFTD. Patients also showed decreased activity in posterior ventral visual regions, specifically the fusiform cortex, possibly reflecting reduced afferent input from limbic regions. Finally, bvFTD was associated with increased activity in posterior regions, including the inferior parietal cortex.Limitations: Autopsy validation of frontotemporal dementia is not yet available for this cohort.Conclusion: Together, these findings suggest that fMRI combined with tasks targeting social-cognitive deficits is a powerful technique to objectively measure neural systems involved in emotion processing in individuals with bvFTD. As viewing emotional expressions is known to engage many of the same neural systems that are active when experiencing the emotion itself, fMRI during expression processing provides a novel window into the emotions of patients with FTD.