RT Journal Article SR Electronic T1 Partially restored resting-state functional connectivity in women recovered from anorexia nervosa JF Journal of Psychiatry and Neuroscience JO J Psychiatry Neurosci FD Canadian Medical Association SP 377 OP 385 DO 10.1503/jpn.150259 VO 41 IS 6 A1 Boehm, Ilka A1 Geisler, Daniel A1 Tam, Friederike A1 King, Joseph A. A1 Ritschel, Franziska A1 Seidel, Maria A1 Bernardoni, Fabio A1 Murr, Julia A1 Goschke, Thomas A1 Calhoun, Vince D. A1 Roessner, Veit A1 Ehrlich, Stefan YR 2016 UL http://jpn.ca/content/41/6/377.abstract AB Background: We have previously shown increased resting-state functional connectivity (rsFC) in the frontoparietal network (FPN) and the default mode network (DMN) in patients with acute anorexia nervosa. Based on these findings we investigated within-network rsFC in patients recovered from anorexia nervosa to examine whether these abnormalities are a state or trait marker of the disease. To extend the understanding of functional connectivity in patients with anorexia nervosa, we also estimated rsFC between large-scale networks.Methods: Girls and women recovered from anorexia nervosa and pair-wise, age- and sex-matched healthy controls underwent a resting-state fMRI scan. Using independent component analyses (ICA), we isolated the FPN, DMN and salience network. We used standard comparisons as well as a hypothesis-based approach to test the findings of our previous rsFC study in this recovered cohort. Temporal correlations between network time-course pairs were computed to investigate functional network connectivity (FNC).Results: Thirty-one patients recovered from anorexia nervosa and 31 controls participated in our study. Standard group comparisons revealed reduced rsFC between the dorsolateral prefrontal cortex (dlPFC) and the FPN in the recovered group. Using a hypothesis-based approach we extended the previous finding of increased rsFC between the angular gyrus and the FPN in patients recovered from anorexia nervosa. No group differences in FNC were revealed.Limitations: The study design did not allow us to conclude that the difference found in rsFC constitutes a scar effect of the disease.Conclusion: This study suggests that some abnormal rsFC patterns found in patients recovered from anorexia nervosa normalize after long-term weight restoration, while distorted rsFC in the FPN, a network that has been associated with cognitive control, may constitute a trait marker of the disorder.