RT Journal Article
SR Electronic
T1 Partially restored resting-state functional connectivity in women recovered from anorexia nervosa
JF Journal of Psychiatry and Neuroscience
JO J Psychiatry Neurosci
FD Canadian Medical Association
SP 377
OP 385
DO 10.1503/jpn.150259
VO 41
IS 6
A1 Ilka Boehm
A1 Daniel Geisler
A1 Friederike Tam
A1 Joseph A. King
A1 Franziska Ritschel
A1 Maria Seidel
A1 Fabio Bernardoni
A1 Julia Murr
A1 Thomas Goschke
A1 Vince D. Calhoun
A1 Veit Roessner
A1 Stefan Ehrlich
YR 2016
UL http://jpn.ca/content/41/6/377.abstract
AB Background: We have previously shown increased resting-state functional connectivity (rsFC) in the frontoparietal network (FPN) and the default mode network (DMN) in patients with acute anorexia nervosa. Based on these findings we investigated within-network rsFC in patients recovered from anorexia nervosa to examine whether these abnormalities are a state or trait marker of the disease. To extend the understanding of functional connectivity in patients with anorexia nervosa, we also estimated rsFC between large-scale networks.Methods: Girls and women recovered from anorexia nervosa and pair-wise, age- and sex-matched healthy controls underwent a resting-state fMRI scan. Using independent component analyses (ICA), we isolated the FPN, DMN and salience network. We used standard comparisons as well as a hypothesis-based approach to test the findings of our previous rsFC study in this recovered cohort. Temporal correlations between network time-course pairs were computed to investigate functional network connectivity (FNC).Results: Thirty-one patients recovered from anorexia nervosa and 31 controls participated in our study. Standard group comparisons revealed reduced rsFC between the dorsolateral prefrontal cortex (dlPFC) and the FPN in the recovered group. Using a hypothesis-based approach we extended the previous finding of increased rsFC between the angular gyrus and the FPN in patients recovered from anorexia nervosa. No group differences in FNC were revealed.Limitations: The study design did not allow us to conclude that the difference found in rsFC constitutes a scar effect of the disease.Conclusion: This study suggests that some abnormal rsFC patterns found in patients recovered from anorexia nervosa normalize after long-term weight restoration, while distorted rsFC in the FPN, a network that has been associated with cognitive control, may constitute a trait marker of the disorder.