TY - JOUR T1 - Common susceptibility variants are shared between schizophrenia and psoriasis in the Han Chinese population JF - Journal of Psychiatry and Neuroscience JO - J Psychiatry Neurosci SP - 413 LP - 421 DO - 10.1503/jpn.150210 VL - 41 IS - 6 AU - Xianyong Yin AU - Nathan E. Wineinger AU - Kai Wang AU - Weihua Yue AU - Nina Norgren AU - Ling Wang AU - Weiyi Yao AU - Xiaoyun Jiang AU - Bo Wu AU - Yong Cui AU - Changbing Shen AU - Hui Cheng AU - Fusheng Zhou AU - Gang Chen AU - Xianbo Zuo AU - Xiaodong Zheng AU - Xing Fan AU - Hongyan Wang AU - Lifang Wang AU - Jimmy Lee AU - Max Lam AU - E. Shyong Tai AU - Zheng Zhang AU - Qiong Huang AU - Liangdan Sun AU - Jinhua Xu AU - Sen Yang AU - Kirk C. Wilhelmsen AU - Jianjun Liu AU - Nicholas J. Schork AU - Xuejun Zhang Y1 - 2016/11/01 UR - http://jpn.ca/content/41/6/413.abstract N2 - Background: Previous studies have shown that individuals with schizophrenia have a greater risk for psoriasis than a typical person. This suggests that there might be a shared genetic etiology between the 2 conditions. We aimed to characterize the potential shared genetic susceptibility between schizophrenia and psoriasis using genome-wide marker genotype data.Methods: We obtained genetic data on individuals with psoriasis, schizophrenia and control individuals. We applied a marker-based coheritability estimation procedure, polygenic score analysis, a gene set enrichment test and a least absolute shrinkage and selection operator regression model to estimate the potential shared genetic etiology between the 2 diseases. We validated the results in independent schizophrenia and psoriasis cohorts from Singapore.Results: We included 1139 individuals with psoriasis, 744 with schizophrenia and 1678 controls in our analysis, and we validated the results in independent cohorts, including 441 individuals with psoriasis (and 2420 controls) and 1630 with schizophrenia (and 1860 controls). We estimated that a large fraction of schizophrenia and psoriasis risk could be attributed to common variants (h2SNP = 29% ± 5.0%, p = 2.00 × 10−8), with a coheritability estimate between the traits of 21%. We identified 5 variants within the human leukocyte antigen (HLA) gene region, which were most likely to be associated with both diseases and collectively conferred a significant risk effect (odds ratio of highest risk quartile = 6.03, p < 2.00 × 10−16). We discovered that variants contributing most to the shared heritable component between psoriasis and schizophrenia were enriched in antigen processing and cell endoplasmic reticulum.Limitations: Our sample size was relatively small. The findings of 5 HLA gene variants were complicated by the complex structure in the HLA region.Conclusion: We found evidence for a shared genetic etiology between schizophrenia and psoriasis. The mechanism for this shared genetic basis likely involves immune and calcium signalling pathways. ER -