@article {KimE639, author = {Nambeom Kim and Eunsoo Won and Seo-Eun Cho and Chang-Ki Kang and Seung-Gul Kang}, title = {Thalamocortical functional connectivity in patients with insomnia using resting-state fMRI}, volume = {46}, number = {6}, pages = {E639--E646}, year = {2021}, doi = {10.1503/jpn.210066}, publisher = {Journal of Psychiatry and Neuroscience}, abstract = {Background: Insomnia is a common disorder that affects a vast number of patients; the hyperarousal theory of insomnia postulates that patients with insomnia are physiologically activated not only at nighttime but also during the daytime. We aimed to investigate the differences in the resting-state functional connectivity (RSFC) of the thalamus with cortical areas between patients with insomnia disorder and healthy controls.Methods: All participants completed clinical questionnaires and underwent portable polysomnography and resting-state fMRI.Results: Patients in the insomnia group (n = 50) showed increased RSFC between the thalamus and right medial superior frontal area, bilateral middle temporal areas, left rectus and right parahippocampal areas compared with controls (n = 42) after controlling for age, sex and education level. Among the pairs that showed increased connectivity, several functional connections were negatively correlated with sleep efficiency, measured by polysomnography.Limitations: We used a small sample size.Conclusion: We consider these results on increased thalamocortical hyperactivity in brain areas related to sensory functions as providing evidence for the hyperarousal theory of insomnia.}, issn = {1180-4882}, URL = {https://www.jpn.ca/content/46/6/E639}, eprint = {https://www.jpn.ca/content/46/6/E639.full.pdf}, journal = {Journal of Psychiatry and Neuroscience} }