@article {OverbeekE702, author = {Gregory Overbeek and Timothy J. Gawne and Meredith A. Reid and Nina V. Kraguljac and Adrienne C. Lahti}, title = {A multimodal neuroimaging study investigating resting-state connectivity, glutamate and GABA at 7 T in first-episode psychosis}, volume = {46}, number = {6}, pages = {E702--E710}, year = {2021}, doi = {10.1503/jpn.210107}, publisher = {Journal of Psychiatry and Neuroscience}, abstract = {Background: The major excitatory and inhibitory neurometabolites in the brain, glutamate and γ-aminobutyric acid (GABA), respectively, are related to the functional MRI signal. Disruption of resting-state functional MRI signals has been reported in psychosis spectrum disorders, but few studies have investigated the role of these metabolites in this context.Methods: We included 19 patients with first-episode psychosis and 21 healthy controls in this combined magnetic resonance spectroscopy (MRS) and resting-state functional connectivity study. All imaging was performed on a Siemens Magnetom 7 T MRI scanner. Both the MRS voxel and the seed for functional connectivity analysis were located in the dorsal anterior cingulate cortex (ACC). We used multiple regressions to test for an interaction between ACC brain connectivity, diagnosis and neurometabolites.Results: ACC brain connectivity was altered in first-episode psychosis. The relationship between ACC glutamate and ACC functional connectivity differed between patients with first-episode psychosis and healthy controls in the precuneus, retrosplenial cortex, supramarginal gyrus and angular gyrus. As well, the relationship between ACC GABA and ACC functional connectivity differed between groups in the caudate, putamen and supramarginal gyrus.Limitations: We used a small sample size. As well, although they were not chronically medicated, all participants were medicated during the study.Conclusion: We demonstrated a link between the major excitatory and inhibitory brain metabolites and resting-state functional connectivity in healthy participants, as well as an alteration in this relationship in patients with first-episode psychosis. Combining data from different imaging modalities may help our mechanistic understanding of the relationship between major neurometabolites and brain network dynamics, and shed light on the pathophysiology of first-episode psychosis.}, issn = {1180-4882}, URL = {https://www.jpn.ca/content/46/6/E702}, eprint = {https://www.jpn.ca/content/46/6/E702.full.pdf}, journal = {Journal of Psychiatry and Neuroscience} }