PT - JOURNAL ARTICLE AU - Sereena Pigeon AU - Michelle Lonergan AU - Olivia Rotondo AU - Roger K. Pitman AU - Alain Brunet TI - Impairing memory reconsolidation with propranolol in healthy and clinical samples: a meta-analysis AID - 10.1503/jpn.210057 DP - 2022 Mar 31 TA - Journal of Psychiatry and Neuroscience PG - E109--E122 VI - 47 IP - 2 4099 - http://jpn.ca/content/47/2/E109.short 4100 - http://jpn.ca/content/47/2/E109.full SO - JPN2022 Mar 31; 47 AB - Background Reconsolidation impairment using propranolol is a novel intervention for mental disorders with an emotional memory at their core. In this systematic review and meta-analysis, we examined the evidence for this intervention in healthy and clinical adult samples.Methods We searched 8 databases for randomized, double-blind studies that involved at least 1 propranolol group and 1 placebo group. We conducted a meta-analysis of 14 studies (n = 478) in healthy adults and 12 studies in clinical samples (n = 446).Results Compared to placebo, reconsolidation impairment under propranolol resulted in reduced recall of aversive material and cue-elicited conditioned emotional responses in healthy adults, as evidenced by an effect size (Hedges g) of −0.51 (p = 0.002, 2-tailed). Moreover, compared to placebo, reconsolidation impairment under propranolol alleviated psychiatric symptoms and reduced cue-elicited reactivity in clinical samples with posttraumatic stress disorder, addiction or phobia (g = −0.42, p = 0.010).Limitations Methodological differences between studies posed an obstacle for identifying sources of heterogeneity.Conclusion Reconsolidation impairment is a robust, well-replicated phenomenon in humans. Its clinical use is promising and deserves further controlled investigation.