TY - JOUR T1 - Childhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume JF - Journal of Psychiatry and Neuroscience JO - JPN SP - E209 LP - E217 DO - 10.1503/jpn.210178 VL - 47 IS - 3 AU - Leilei Wang AU - Yi Yin AU - Wei Feng AU - Yanfang Zhou AU - Junchao Huang AU - Ping Zhang AU - Song Chen AU - Hongzhen Fan AU - Yimin Cui AU - Xingguang Luo AU - Shuping Tan AU - Zhiren Wang AU - Baopeng Tian AU - Li Tian AU - Chiang-Shan R. Li AU - Yunlong Tan Y1 - 2022/06/07 UR - http://jpn.ca/content/47/3/E209.abstract N2 - Background: A line of evidence has shown that childhood trauma and patterns of H-shaped sulci in the orbitofrontal cortex (OFC) are associated with cognitive deficits in patients with schizophrenia. Studies have also suggested that childhood trauma is associated with OFC volumetrics. This study investigated the interrelationship between childhood trauma, OFC H-shaped sulci volume and cognitive function in patients with first-episode schizophrenia. We hypothesized that OFC H-shaped sulci volume would mediate the relationship between childhood trauma and cognitive function in patients with first-episode schizophrenia.Methods: We recruited patients with first-episode schizophrenia (n = 63) and healthy controls (n = 48), and quantified OFC H-shaped sulci volumes with 3.0 T high-resolution MRI. We assessed cognitive function and childhood trauma experiences using the MATRICS Consensus Cognitive Battery (MCCB) and the Childhood Trauma Questionnaire (CTQ).Results: Patients with first-episode schizophrenia had smaller left OFC H-shaped sulci volumes, more severe childhood trauma experiences and worse cognitive function than healthy controls. CTQ total score and emotional and physical neglect subscores were negatively correlated with left OFC H-shaped sulci volume. CTQ total score and emotional neglect and sexual abuse subscores were negatively correlated with cognitive function in patients with first-episode schizophrenia. Interestingly, the CTQ total score and physical neglect subscore were positively correlated with cognitive function in healthy controls. Left OFC H-shaped sulci volume played a mediating role in CTQ emotional neglect subscore, CTQ total score and MCCB composite score.Limitations: The small sample size and retrospective design need to be considered.Conclusion: Childhood trauma might contribute to cognitive deficits in patients with first-episode schizophrenia by affecting left OFC H-shaped sulci volume. This finding can help in the design of strategies to improve cognitive function in patients with first-episode schizophrenia. ER -