TY - JOUR T1 - Identifying common and distinct subcortical volumetric abnormalities in 3 major psychiatric disorders: a single-site analysis of 640 participants JF - Journal of Psychiatry and Neuroscience JO - JPN SP - E230 LP - E238 DO - 10.1503/jpn.210154 VL - 47 IS - 3 AU - Pei-Chi Tu AU - Wan-Chen Chang AU - Mu-Hong Chen AU - Ju-Wei Hsu AU - Wei-Chen Lin AU - Cheng-Ta Li AU - Tung-Ping Su AU - Ya-Mei Bai Y1 - 2022/06/22 UR - http://jpn.ca/content/47/3/E230.abstract N2 - Background Subcortical volumetric abnormalities in schizophrenia, bipolar disorder and major depressive disorder (MDD) have been consistently found on a single-diagnosis basis in previous studies. However, whether such volumetric abnormalities are specific to a particular disorder or shared by other disorders remains unclear.Methods We analyzed the structural MRIs of 160 patients with schizophrenia, 160 patients with bipolar disorder, 160 patients with MDD and 160 healthy controls. We calculated the volumes of the thalamus, hippocampus, amygdala, accumbens, putamen, caudate, pallidum and lateral ventricles using FreeSurfer 7.0 and compared them among the groups using general linear models.Results We found a significant group effect on the volumes of the thalamus, hippocampus, accumbens and pallidum. Further post hoc analysis revealed that thalamic volumes in patients with schizophrenia, bipolar disorder and MDD were significantly reduced compared to those in healthy controls, but did not differ from one another. Patients with schizophrenia and bipolar disorder also shared a significant reduction in hippocampal volumes. Among the 3 clinical groups, patients with schizophrenia showed significantly lower hippocampal volumes and higher pallidal volumes than patients with bipolar disorder and MDD.Limitations Differences in psychotropic use and duration of illness among the patient groups may limit the interpretation of our findings.Conclusion Our findings indicate that decreased thalamic volume is a common feature of schizophrenia, bipolar disorder and MDD. Smaller hippocampal and larger pallidal volumes differentiate schizophrenia from bipolar disorder and MDD and may provide clues to the biological basis for the Kraepelinian distinction between these illnesses. ER -