RT Journal Article
SR Electronic
T1 Reduced signal propagation elicited by frontal transcranial magnetic stimulation is associated with oligodendrocyte abnormalities in treatment-resistant depression
JF Journal of Psychiatry and Neuroscience
JO JPN
FD Canadian Medical Association
SP E325
OP E335
DO 10.1503/jpn.220102
VO 47
IS 5
A1 Masataka Wada
A1 Shinichiro Nakajima
A1 Shiori Honda
A1 Mayuko Takano
A1 Keita Taniguchi
A1 Sakiko Tsugawa
A1 Yu Mimura
A1 Nanao Hattori
A1 Shinsuke Koike
A1 Reza Zomorrodi
A1 Daniel M. Blumberger
A1 Zafiris J. Daskalakis
A1 Masaru Mimura
A1 Yoshihiro Noda
YR 2022
UL http://jpn.ca/content/47/5/E325.abstract
AB Background: The efficacy of repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (dlPFC) has been established in patients with treatment-resistant depression (TRD), suggesting that alterations in signal propagation from the left dlPFC to other brain regions may be linked to the pathophysiology of TRD. Alterations at the cellular level, including dysfunction of oligodendrocytes, may contribute to these network abnormalities. The objectives of the present study were to compare signal propagation from the left dlPFC to other neural networks in patients with TRD and healthy controls. We used TMS combined with electroencephalography to explore links between cell-specific gene expression and signal propagation in TRD using a virtual-histology approach.Methods: We examined source-level estimated signal propagation from the left dlPFC to the 7 neural networks in 60 patients with TRD and 30 healthy controls. We also calculated correlations between the interregional profiles of altered signal propagation and gene expression for 9 neural cell types derived from the Allen Human Brain Atlas data set.Results: Signal propagation from the left dlPFC to the salience network was reduced in the θ and α bands in patients with TRD (p = 0.0055). Furthermore, this decreased signal propagation was correlated with cellspecific gene expression of oligodendrocytes (p < 0.000001).Limitations: These results show only part of the pathophysiology of TRD, because stimulation was limited to the left dlPFC.Conclusion: Reduced signal propagation from the left dlPFC to the salience network may represent a pathophysiological endophenotype of TRD; this finding may be associated with reduced expression of oligodendrocytes.