Table 4

Analysis of covariance and descriptive statistics for amygdala measurements^*

Region of interest	Healthy controls v. MDD				Healthy controls v. unmedicated MDD v. medicated MDD

	Healthy controls (n = 35)	MDD (n = 35)	F_1,67	p value^†	Unmedicated MDD (n = 10)	Medicated MDD (n = 25)	F_2,66	p value^‡	Unmedicated MDD v. healthy controls		Medicated MDD v. healthy controls		Unmedicated MDD v. medicated MDD

									F_1,42	p value	F_1,57	p value	F_1,32	p value

Total amygdala	1994 ± 330	1880 ± 307	1.35	0.25	1933 ± 285	1858 ± 319	0.67	0.52	0.88	0.35	1.10	0.30	0.02	0.90
Centromedial group	287 ± 59	278 ± 71	0.06	0.81	306 ± 101	267 ± 54	0.77	0.47	0.45	0.51	1.04	0.31	0.81	0.37
Cortical group	157 ± 29	144 ± 33	1.03	0.31	149 ± 38	142 ± 32	0.51	0.60	0.69	0.41	1.00	0.32	0.02	0.90
Basolateral complex	1552 ± 282	1457 ± 238	1.45	0.23	1477 ± 205	1448 ± 253	0.78	0.46	1.41	0.24	0.83	0.37	0.01	0.94
Lateral nucleus	642 ± 120	598 ± 94	2.02	0.16	596 ± 90	599 ± 98	1.17	0.32	2.22	0.14	0.91	0.34	0.01	0.92
Basal nucleus	618 ± 122	581 ± 105	1.08	0.30	597 ± 100	574 ± 108	0.54	0.59	0.64	0.43	0.84	0.36	0.00	0.96
Accessory basal nucleus	291 ± 57	277 ± 59	0.38	0.54	283 ± 53	274 ± 62	0.23	0.80	0.54	0.47	0.24	0.63	0.05	0.83

MDD = major depressive disorder.
↵* Analysis of covariance of volumes (mm³) of the total amygdala, basolateral, cortical and centromedial groups of the amygdala, as well as the lateral, basal and accessory basal nuclei of the basolateral group (covariate, intracranial volumes). Group (diagnosis or treatment) × hemisphere interactions were not significant; volumes are mean ± standard deviation of both hemispheres.
↵† Diagnosis main effect in 2-group comparison: healthy controls and MDD.
↵‡ Treatment main effect in 3-group comparison: healthy controls, unmedicated MDD and medicated MDD.