Table 3

Main positive effects of alexithymia on brain structure^*

Region	k	t	p_FWE	MNI coordinates, x, y, z
Main effect of alexithymia, independent of group
Left insula	636	3.17	0.024	−34, −8, 10
Right temporal inferior	433	3.27	0.026	56, −3, −32
Left temporal inferior	303	3.31	0.033	−56, −3, −34
Right thalamus	235	2.99	0.044	10, −24, 10
Effect of alexithymia in patients with major depressive disorder
Left insula	45	4.14	0.046	−45, 3, 9
Effect of alexithymia in healthy controls
Right hippocampus, thalamus, fusiform gyrus	1846	4.67	0.010	22, −33, 6
Right medial cingulum	205	3.89	0.034	9, −22, 38
Left and right posterior cingulum	142	3.55	0.039	6, 0, 15
Right fusiform gyrus	22	3.13	0.049	36, −46, −12

FWE = family-wise error; MNI = Montreal Neurological Institute.
↵* Model was an analysis of covariance, with group as a factor and alexithymia sum scores as covariates. Age, sex and total intracranial volume were included as nuisance regressors. Values represent the main effect of alexithymia on brain structure across both groups and in each group in an exploratory whole brain analysis. For brevity, the main effects of alexithymia independent of group are reported only above a cluster size of 200 voxels.