Table 2

Regional [11C]ABP688 BPND values in the Amph and placebo groups

RegionPlaceboAmph
Scan 1 BPNDScan 2 BPNDMean % changep valueScan 1 BPNDScan 2 BPNDMean % changep value
Striatal
 Associative1.1 ± 0.191.2 ± 0.15+100.251.0 ± 0.181.1 ± 0.22+120.14
 Sensorimotor0.88 ± 0.170.96 ± 0.14+140.110.90 ± 0.160.92 ± 0.18+50.47
 Ventral1.2 ± 0.211.3 ± 0.19+110.091.1 ± 0.231.2 ± 0.30+70.39
Cortical
 Medial prefrontal cortex1.0 ± 0.191.1 ± 0.13+60.570.92 ± 0.260.95 ± 0.26+100.42
 Dorsolateral prefrontal cortex0.88 ± 0.150.90 ± 0.13+40.610.77 ± 0.240.83 ± 0.22+130.36
 Orbitofrontal cortex0.81 ± 0.170.87 ± 0.14+110.250.76 ± 0.220.80 ± 0.19+110.39
 Cingulate0.99 ± 0.161.0 ± 0.10+50.660.92 ± 0.200.95 ± 0.21+80.47
 Insula1.0 ± 0.171.1 ± 0.11+110.201.0 ± 0.221.0 ± 0.25+100.37
Limbic subcortical
 Amygdala0.67 ± 0.150.73 ± 0.10+150.190.56 ± 0.150.66 ± 0.20+220.12
 Hippocampus0.66 ± 0.140.73 ± 0.11+160.210.55 ± 0.110.65 ± 0.17+220.10
  • Amph = dextroamphetamine; BPND = binding potential, non-displaceable.

  • Unless otherwise indicated, values are mean ± standard deviation; p values from paired t tests within groups.