Table 2

Meta-analyses of regional differences for task-evoked activation during gain anticipation for participants with addiction and healthy controls

Local maximumClusterEgger’s test (p value)Jackknife sensitivityHeterogeneity
RegionPeak MNI coordinates, x, y, zSDM Z valuep valueVoxels, nBreakdown (voxels, n)
All addictions > healthy controls
 Left angular gyrus, BA 39−52, −56, 301.769< 0.001441Left angular gyrus, BA 39 (158)
Left middle temporal gyrus, BA 21 (47)
Left supramarginal gyrus, BA 40 (45)
Left middle temporal gyrus, BA 22 (36)
Left supramarginal gyrus, BA 22 (29)
Left inferior parietal (excluding supramarginal and angular) gyri, BA 39 (23)
Left supramarginal gyrus, BA 48 (22)
Left angular gyrus, BA 22 (21)
Left middle temporal gyrus, BA 39 (13)		0.1712/12No
 Left precentral gyrus, BA 6−22, −18, 721.4490.00169Left precentral gyrus, BA 6 (67)
Left precentral gyrus (2)		0.6510/12No
 Right precuneus10, −52, 461.2880.00324Right precuneus (20)0.7010/12No
All addictions < healthy controls
 Right temporal pole, superior temporal gyrus, BA 3830, 14, −26−1.5720.001318Right temporal pole, superior temporal gyrus, BA 38 (118)
Right temporal pole, superior temporal gyrus (39)
Right inferior frontal gyrus, orbital part, BA 38 (32)
Right insula, BA 38 (20)
Right parahippocampal gyrus, BA 28 (18)
Right inferior frontal gyrus, orbital part (17)
Right parahippocampal gyrus, BA 38 (11)		0.01510/12No
 Left striatum−16, 16, −12−1.599< 0.001193Left striatum (60)
Left olfactory cortex, BA 25 (28)
Left inferior network, uncinate fasciculus (19)
Left superior frontal gyrus, orbital part, BA 11 (16)
Left inferior frontal gyrus, orbital part, BA 11 (13)
Left gyrus rectus, BA 11 (11)		0.0079/12Yes
 Left supplementary motor area, BA 60, 16, 62−1.685< 0.001163Left supplementary motor area, BA 6 (75)
Right supplementary motor area, BA 6 (32)
Right supplementary motor area, BA 8 (18)
Left supplementary motor area (16)		0.3410/12No
 Left inferior network, inferior longitudinal fasciculus−36, −50, −10−1.766< 0.001159Left inferior network, inferior longitudinal fasciculus (104)
Left fusiform gyrus, BA 37 (39)
Left inferior temporal gyrus, BA 37 (15)		0.0910/12No
 Left inferior frontal gyrus, triangular part, BA 45−50, 30, 6−1.4660.00126—0.8810/12No
Substance dependence > healthy controls
 Left angular gyrus, BA 39−54, −54, 321.548< 0.001910Left angular gyrus, BA 39 (374)
Left middle temporal gyrus, BA 21 (98)
Left middle temporal gyrus, BA 39 (89)
Left supramarginal gyrus, BA 40 (55)
Left middle temporal gyrus, BA 22 (51)
Left middle temporal gyrus, BA 37 (39)
Left supramarginal gyrus, BA 22 (35)
Left superior temporal gyrus, BA 22 (29)
Left inferior parietal (excluding supramarginal and angular) gyri, BA 39 (23)
Left angular gyrus, BA 22 (22)
Left superior temporal gyrus, BA 42 (18)
Left supramarginal gyrus, BA 42 (12)
Left supramarginal gyrus, BA 48 (10)		0.336/8No
 Corpus callosum22, −82, 241.3070.002160Corpus callosum (108)
Right superior occipital gyrus, BA 19 (51)
Right superior occipital gyrus, BA 18 (1)		0.416/8No
 Left middle occipital gyrus, BA 39−40, −78, 181.1250.00424Left middle occipital gyrus, BA 39 (15)
Left inferior network, inferior longitudinal fasciculus (5)
Corpus callosum (3)
Left middle occipital gyrus, BA 19 (1)		0.936/8No
Substance dependence < healthy controls
 Left striatum−16, 16, −12−1.715< 0.001353Left striatum (115)
Left inferior frontal gyrus, orbital part, BA 11 (41)
Left olfactory cortex, BA 25 (33)
Left inferior network, uncinate fasciculus (29)
Left superior frontal gyrus, orbital part, BA 11 (27)
Left gyrus rectus, BA 11 (15)
Corpus callosum (13)
Left lenticular nucleus, putamen, BA 25 (13)		0.0128/8Yes
 Left inferior network, inferior longitudinal fasciculus−36, −50, −12−1.4420.002129Left inferior network, inferior longitudinal fasciculus (78)
Left fusiform gyrus, BA 37 (49)
Left inferior temporal gyrus, BA 37 (2)		0.126/8No
 Right inferior network, inferior fronto-occipital fasciculus34, −18, −4−1.4930.00268Right inferior network, inferior fronto-occipital fasciculus (18)
Corpus callosum (11)
Right lenticular nucleus, putamen, BA 48 (10)
Right insula, BA 48 (4)
Right striatum (2)		0.176/8No
 Left middle frontal gyrus, BA 46−26, 46, 30−1.420.00251Left middle frontal gyrus, BA 46 (37)
Left middle frontal gyrus, BA 9 (9)
Left middle frontal gyrus (5)		0.076/8No
 Left supplementary motor area, BA 6−2, 12, 58−1.546< 0.00145Left supplementary motor area, BA 6 (41)
Left supplementary motor area (3)
Right supplementary motor area, BA 6 (1)		0.326/8No
 Right inferior network, inferior longitudinal fasciculus30, −22, −8−1.4720.00224Right hippocampus, BA 20 (10)
Corpus callosum (5)
Right inferior network, inferior longitudinal fasciculus (3)
Right optic radiations (2)
Right inferior network, inferior fronto-occipital fasciculus (1)		0.266/8No

  • BA = Brodmann area; MNI = Montreal Neurological Institute; SDM = seed-based d-mapping.