Local maximum | Cluster | Egger’s test (p value) | Jackknife sensitivity | Heterogeneity | ||||
---|---|---|---|---|---|---|---|---|
Region | Peak MNI coordinates, x, y, z | SDM Z value | p value | Voxels, n | Breakdown (voxels, n) | |||
All addictions > healthy controls | ||||||||
Left postcentral gyrus, BA 4 | −50, −18, 46 | 1.416 | < 0.001 | 533 | Left postcentral gyrus, BA 4 (223) Left postcentral gyrus, BA 3 (130) Left postcentral gyrus, BA 6 (85) Left inferior parietal (excluding supramarginal and angular) gyri, BA 3 (48) Left precentral gyrus, BA 6 (17) Left postcentral gyrus (11) | 0.34 | 8/10 | No |
Corpus callosum | 14, −14, 66 | 1.167 | 0.002 | 313 | Right precentral gyrus, BA 6 (142) Corpus callosum (57) Right precentral gyrus, BA 4 (36) Right superior frontal gyrus, dorsolateral, BA 6 (22) Right supplementary motor area, BA 6 (21) Right postcentral gyrus, BA 4 (21) Right corticospinal projections (9) Right postcentral gyrus, BA 3 (3) Right precentral gyrus (1) Right postcentral gyrus (1) | 0.28 | 8/10 | No |
Left middle frontal gyrus, BA 10 | −32, 56, 4 | 1.239 | 0.001 | 180 | Left middle frontal gyrus, BA 10 (100) Left superior frontal gyrus, dorsolateral, BA 10 (27) Left anterior thalamic projections (12) | 0.16 | 8/10 | No |
Right striatum | 24, 12, 4 | 1.279 | < 0.001 | 127 | Right striatum (91) Right lenticular nucleus, putamen, BA 48 (17) Right superior longitudinal fasciculus III (10) Right inferior network, inferior fronto-occipital fasciculus (4) Right lenticular nucleus, putamen (3) Right fronto-insular tract 3 (2) | 0.48 | 8/10 | No |
Right inferior frontal gyrus, opercular part, BA 48 | 50, 10, 6 | 1.02 | 0.004 | 19 | Right inferior frontal gyrus, opercular part, BA 48 (14) Right frontal aslant tract (4) Right insula (1) | 0.16 | 8/10 | No |
All addictions < healthy controls | ||||||||
Left striatum | −14, 14, −6 | −1.578 | < 0.001 | 1295 | Left striatum (291) Left inferior network, uncinate fasciculus (98) Left lenticular nucleus, putamen, BA 48 (85) Left temporal pole, superior temporal gyrus, BA 38 (71) Left inferior network, inferior longitudinal fasciculus (71) Left caudate nucleus, BA 25 (44) Anterior commissure (40) Left inferior temporal gyrus, BA 20 (36) Left temporal pole, middle temporal gyrus, BA 20 (35) Left anterior thalamic projections (33) Left temporal pole, middle temporal gyrus, BA 38 (27) Left olfactory cortex, BA 25 (23) Right striatum (22) Corpus callosum (21) Left middle temporal gyrus, BA 20 (19) Left amygdala, BA 34 (17) Left temporal pole, superior temporal gyrus, BA 48 (16) Left temporal pole, superior temporal gyrus (16) Left inferior network, inferior fronto-occipital fasciculus (14) Left temporal pole, superior temporal gyrus, BA 20 (14) Right olfactory cortex, BA 25 (13) Left pons (13) Left temporal pole, middle temporal gyrus, BA 21 (12) Left lenticular nucleus, putamen, BA 25 (11) | 0.022 | 9/10 | No |
Left inferior frontal gyrus, triangular part, BA 45 | −50, 22, 4 | −1.45 | < 0.001 | 458 | Left inferior frontal gyrus, triangular part, BA 45 (277) Left inferior frontal gyrus, triangular part, BA 47 (46) Left superior longitudinal fasciculus III (45) Corpus callosum (37) Left inferior frontal gyrus, triangular part, BA 48 (16) Left inferior frontal gyrus, orbital part, BA 47 (13) | 0.57 | 8/10 | No |
Left inferior network, inferior longitudinal fasciculus | −24, −82, −10 | −1.425 | < 0.001 | 338 | Left inferior network, inferior longitudinal fasciculus (107) Left fusiform gyrus, BA 19 (81) Left lingual gyrus, BA 18 (61) Left fusiform gyrus, BA 18 (43) Left inferior occipital gyrus, BA 19 (21) Left inferior occipital gyrus, BA 18 (11) | 0.48 | 8/10 | No |
Left calcarine fissure/ surrounding cortex, BA 18 | −18, −66, 16 | −1.515 | < 0.001 | 239 | Corpus callosum (127) Left middle occipital gyrus, BA 19 (28) Left calcarine fissure/surrounding cortex, BA 18 (23) Left calcarine fissure/surrounding cortex, BA 17 (13) Left cuneus cortex, BA 18 (11) | 0.56 | 9/10 | No |
Substance dependence > healthy controls | ||||||||
None | ||||||||
Substance dependence < healthy controls | ||||||||
Left lingual gyrus, BA 18 | −22, −82, −16 | −1.579 | < 0.001 | 727 | Left inferior network, inferior longitudinal fasciculus (220) Left fusiform gyrus, BA 19 (160) Left lingual gyrus, BA 18 (110) Left fusiform gyrus, BA 18 (82) Left cerebellum, hemispheric lobule VI, BA 18 (50) Left inferior occipital gyrus, BA 19 (26) Left inferior occipital gyrus, BA 18 (17) Left lingual gyrus, BA 19 (15) Left fusiform gyrus, BA 37 (14) Left cerebellum, hemispheric lobule VI, BA 19 (13) | 0.72 | 5/7 | No |
Corpus callosum | −18, −68, 18 | −1.569 | < 0.001 | 385 | Corpus callosum (184) Left middle occipital gyrus, BA 19 (46) Left calcarine fissure/surrounding cortex, BA 18 (34) Left calcarine fissure/surrounding cortex, BA 17 (34) Left superior occipital gyrus, BA 18 (12) Left cuneus cortex, BA 18 (11) Left cuneus cortex, BA 23 (10) Left cuneus cortex (10) Left inferior network, inferior longitudinal fasciculus (5) Left superior occipital gyrus (3) Left calcarine fissure/surrounding cortex, BA 23 (2) Left cuneus cortex, BA 17 (1) Left superior occipital gyrus, BA 23 (1) Left middle occipital gyrus, BA 39 (1) | 0.82 | 6/7 | No |
Left lenticular nucleus, putamen | −30, −6, −4 | −1.211 | 0.002 | 147 | Left striatum (69) Left lenticular nucleus, putamen, BA 48 (42) Left pons (11) Left lenticular nucleus, putamen (10) Left inferior network, inferior fronto-occipital fasciculus (2) Left corticospinal projections (2) Left lenticular nucleus, putamen, BA 34 (1) | 0.75 | 5/7 | No |
BA = Brodmann area; MNI = Montreal Neurological Institute; SDM = seed-based d-mapping.