Multi-adjusted Cox proportional hazards analysis for the association between CYP11B1 polymorphisms and 14-year incidence of depression according to history of major depression in women
| SNP and genotype | Risk of incident recurrent depression (n = 109) | Risk of incident late-onset depression (n = 269) | ||||||
|---|---|---|---|---|---|---|---|---|
| No depression | Depression* | HR (95% CI)† | p value | No depression | Depression* | HR (95% CI)† | p value | |
| rs11783855, n | 56 | 53 | 174 | 90 | ||||
| GG, % | 16.07 | 30.19 | — | — | 32.18 | 23.33 | — | — |
| GT, % | 55.36 | 50.94 | 0.68 (0.35–1.33) | 0.26 | 52.30 | 34.44 | 0.97 (0.55–1.69) | 0.91 |
| TT, % | 28.57 | 18.87 | 0.60 (0.27–1.37) | 0.23 | 15.52 | 42.22 | 2.36 (1.37–4.05) | 0.002 |
| rs1134096, n | 56 | 53 | 175 | 89 | ||||
| TT, % | 32.14 | 30.19 | — | — | 32.00 | 33.71 | — | — |
| GT, % | 44.64 | 47.17 | 1.09 (0.55–2.16) | 0.81 | 56.57 | 46.07 | 0.74 (0.46–1.19) | 0.21 |
| GG, % | 23.21 | 22.64 | 1.17 (0.53–2.56) | 0.70 | 11.43 | 20.22 | 1.81 (1.00–3.27) | 0.05 |
| rs7011830, n | 55 | 56 | 169 | 88 | ||||
| CC, % | 30.91 | 32.61 | — | — | 31.36 | 34.09 | — | — |
| AC, % | 45.45 | 43.48 | 1.03 (0.49–2.14) | 0.95 | 57.99 | 47.73 | 0.73 (0.45–1.18) | 0.20 |
| AA, % | 23.64 | 23.91 | 1.26 (0.55–2.89) | 0.58 | 10.65 | 18.18 | 1.73 (0.93–3.19) | 0.08 |
| rs6471580, n | 56 | 53 | 173 | 89 | ||||
| AA, % | 28.57 | 30.19 | — | — | 16.76 | 28.09 | — | — |
| AG, % | 44.64 | 43.40 | 0.80 (0.41–1.56) | 0.51 | 60.12 | 49.44 | 0.42 (0.25–0.69) | 0.0007 |
| GG, % | 26.79 | 26.42 | 0.70 (0.32–1.50) | 0.36 | 23.12 | 22.47 | 0.58 (0.32–1.05) | 0.07 |
| rs7016924, n | 56 | 51 | 176 | 90 | ||||
| GG, % | 30.36 | 33.33 | — | — | 20.45 | 31.11 | — | — |
| AG, % | 44.64 | 45.10 | 0.80 (0.42–1.54) | 0.51 | 58.52 | 48.89 | 0.46 (0.28–0.75) | 0.002 |
| AA, % | 25.00 | 21.57 | 0.64 (0.28–1.46) | 0.29 | 21.02 | 20.00 | 0.60 (0.33–1.10) | 0.10 |
CES-D = Center for Epidemiologic Studies-Depression; CI = confidence interval; HR = hazard ratio; MMSE = Mini-Mental State Examination; SNP = single nucleotide polymorphism.
↵* Current major depression or a CES-D score ≥ 16 (37.8% incidence).
↵† Cox model with age as timescale and adjusted for ischemic pathologies, body mass index, hypertension, cognitive impairment (MMSE < 26) and current anxiety disorder, as well as for history of major depression for the entire sample of women.