p value thresholds | β | p value | SNP count |
---|---|---|---|
PRS т 0.0001 | −0.113 | 0.31 | 2493 |
PRS т 0.001 | −0.055 | 0.61 | 6764 |
PRS т 0.01 | −0.184 | 0.12 | 23 929 |
PRS т 0.05 | −0.145 | 0.24 | 65 567 |
PRS т 0.1 | −0.189 | 0.13 | 103 097 |
PRS т 0.2 | −0.151 | 0.25 | 161 534 |
PRS т 0.3 | −0.144 | 0.28 | 208 446 |
PRS т 0.4 | −0.152 | 0.25 | 248 433 |
PRS т 0.5 | −0.156 | 0.24 | 282 935 |
GWAS = genome-wide association studies; MAVAN = Maternal Adversity, Vulnerability and Neurodevelopment. PRS = polygenic risk score; SNP = single nucleotide polymorphism.
↵* Association between PRSs using the GWAS for total brain volume63 and total brain volume in MAVAN children, with different PRS p value thresholds. We adjusted the regression models using the principal components of age, sex, site and population stratification.