Distribution of [3H]-AFDX-384 binding sites in selected brain regions of 15-month-old WKY and SHR rats
| Brain area | Rat strain; mean (and SEM) binding, nCi bound [3H]/mg wet tissue, n = 5–6 | |
|---|---|---|
| WKY | SHR | |
| Amygdaloid nuc., basolateral | 8.29 (0.83) | 9.73 (0.05) |
| Amygdaloid nuc., central | 5.41 (1.12) | 3.76 (0.05) |
| Accumbens nucleus | 10.44 (0.08) | 10.67 (0.05) |
| Caudate putamen* | 9.92 (0.07) | 10.37 (0.06) |
| Diagonal band | 3.69 (0.36) | 3.93 (0.25) |
| Substantia inominata | 2.20 (0.22) | 2.68 (0.54) |
| Cerebral cortex | ||
| Cingulate | 5.63 (0.67) | 7.00 (0.86) |
| Cingulate area 1 | 5.92 (0.66) | 5.73 (0.65) |
| Frontal association | 8.30 (0.71) | 8.20 (0.66) |
| Infralimbic | 7.88 (0.78) | 8.81 (0.17) |
| Insular | 7.96 (0.60) | 8.40 (0.39) |
| Motor area 1 | 6.78 (0.59) | 7.24 (0.49) |
| Motor area 2 | 7.08 (0.60) | 8.09 (0.47) |
| Orbital | 7.74 (0.88) | 8.55 (0.48) |
| Parietal | 7.08 (0.47) | 7.15 (0.66) |
| Piriform | 4.83 (0.28) | 5.49 (0.51) |
| Prefrontal | 8.37 (0.59) | 8.38 (0.65) |
| Retrosplenial | 4.92 (0.17) | 6.38 (0.86) |
| Somatosensory | 6.95 (0.60) | 7.44 (0.58) |
| Anterior olfactory nuc. | 6.24 (0.69) | 6.47 (0.23) |
| DG outer and inner blade | 5.94 (0.39) | 4.43 (0.34) |
| DG polymorph layer | 4.07 (0.13) | 3.71 (0.12) |
| Hipp. form. CA1 region | 8.31 (0.27) | 7.83 (0.57) |
| Hipp. form. CA2 and 3 region | 3.69 (0.05) | 3.47 (0.18) |
| Olfactory tubercle | 10.40 (0.11) | 10.60 (0.07) |
| Bed nuc. of stria terminalis | 2.60 (0.14) | 2.85 (0.29) |
| Septal nuc., lateral | 4.47 (0.78) | 3.56 (0.22) |
| Septal nuc., medial | 3.31 (0.46) | 2.45 (0.23) |
| Dorsal peduncular nuc. | 7.59 (0.77) | 8.27 (0.15) |
| Hypothalamic nuc. | ||
| Dorsomedial | 2.62 (0.18) | 2.64 (0.59) |
| Lateral | 2.36 (0.14) | 2.66 (0.19) |
| Ventromedial | 2.24 (0.17) | 2.57 (0.34) |
| Medial preoptic area | 2.55 (0.15) | 2.64 (0.30) |
| Zona incerta | 2.41 (0.19) | 2.43 (0.11) |
| Thalamic nuc. | ||
| Anteroventral | 5.04 (0.35) | 5.44 (0.78) |
| Laterodorsal | 3.25 (0.16) | 3.13 (0.28) |
| Mediodorsal | 3.42 (0.16) | 3.54 (0.23) |
| Paraventricular | 2.87 (0.16) | 2.95 (0.13) |
| Rhomboid | 3.19 (0.22) | 3.73 (0.44) |
| Ventromedial | 2.49 (0.12) | 2.43 (0.20) |
| Ventroposterior | 2.02 (0.09) | 1.98 (0.11) |
| Central periaqueductal gray | 2.29 (0.20) | 2.04 (0.20) |
| Dorsal tegmental nuc. | 2.49 (0.25) | 2.84 (0.26) |
| Parabrachial nuc. | 3.37 (0.39) | 3.91 (0.31) |
| Pontine nuc. | 5.74 (1.13) | 8.31 (0.62) |
| Trigeminal nuc. | 5.79 (0.85) | 7.03 (1.07) |
| Gigantocellular nuc. | 1.91 (0.25) | 2.25 (0.21) |
| Paragigantocellular nuc., dorsal | 1.85 (0.13) | 1.85 (0.20) |
| Reticular nuc. RVL | 4.40 (0.51) | 6.08 (1.46) |
| Vestibular nuc. | 2.27 (0.16) | 2.80 (0.25) |
Note: DG = dentate gyrus, RVL = rostroventrolateral; hipp. form. = hippocampal formation. Whole brains were sectioned from the prefrontal cortex through the pons.
↵* Significant difference between phenotypes (SHR > WKY, p < 0.01).