Effect of quinine on the anti-immobility effects of the 4 MAO inhibitors
| MAO inhibitor; dose, mg/kg | Treatment; mean period of immobility (and SEM), s | % change† | |
|---|---|---|---|
| Single drug* | Interaction (quinine + MAO inhibitor) | ||
| TCP | |||
| 0.0 | 217 (4) | NA | |
| 0.5 | 223 (4) | 206 (5) | −8 |
| 2.0 | 189 (6) | 187 (9) | −1 |
| 8.0 | 155‡ (14) | 178‡ (10) | +10 |
| FTCP | |||
| 0.0 | 227 (3) | NA | |
| 0.5 | 235 (9) | 221 (18) | −6 |
| 2.0 | 236 (6) | 234 (14) | −1 |
| 8.0 | 222 (23) | 216 (22) | −3 |
| PLZ | |||
| 0.0 | 231 (3) | NA | |
| 2.0 | 232 (2) | 225 (4) | −3 |
| 8.0 | 228 (3) | 223 (4) | −2 |
| 32.0 | 227 (4) | 226 (4) | 0 |
| AcPLZ | |||
| 0.0 | 221 (5) | NA | |
| 2.0 | 227 (3) | 194‡ (5) | −15§ |
| 8.0 | 221 (4) | 196‡ (9) | −11¶ |
| 32.0 | 223 (3) | 178‡ (6) | −21§ |
↵* For zero doses of the 4 MAO inhibitors, the data are for quinine alone (0.5 mg/kg).
↵† Calculated as (% interaction – % MAO inhibitor alone), where the percentages are calculated with respect to mean periods of immobility for control (vehicle). Mean period of immobility (and SEM) for controls, in seconds: TCP 216 (4), FTCP 231 (2), PLZ 231 (3), AcPLZ 221 (5).
↵‡ Significantly different from vehicle (p < 0.01) (Sidak’s test, n = 10).
↵§ Significantly different from AcPLZ alone (p < 0.01) (Sidak’s test, n = 10).
↵¶ Significantly different from AcPLZ alone (p < 0.05) (Sidak’s test, n = 10).