Effect of clonidine on anti-immobility effects of the 4 MAO inhibitors
| MAO inhibitor; dose, mg/kg | Treatment; mean period of immobility (and SEM), s | % change† | p value‡ | |
|---|---|---|---|---|
| Single drug* | Interaction (clonidine + MAO inhibitor) | |||
| TCP | < 0.001 | |||
| 0.0 | 188 (21) | NA | NA | |
| 0.5 | 204 (12) | 163§ (19) | −17 | |
| 2.0 | 214 (12) | 133§¶ (25) | −35 | |
| 8.0 | 170§ (15) | 102§ (25) | −30 | |
| FTCP | < 0.001 | |||
| 0.0 | 230 (2) | NA | NA | |
| 0.5 | 228 (3) | 191¶ (6) | −16 | |
| 2.0 | 208 (17) | 173§¶ (11) | −15 | |
| 8.0 | 191 (13) | 129§¶ (22) | −27 | |
| PLZ | < 0.001 | |||
| 0.0 | 214 (6) | NA | NA | |
| 2.0 | 223 (5) | 170 (22) | −23 | |
| 8.0 | 235 (2) | 143§¶ (21) | −42 | |
| 32.0 | 231 (3) | 170¶ (13) | −27 | |
| AcPLZ | < 0.001 | |||
| 0.0 | 214 (6) | NA | NA | |
| 2.0 | 219 (10) | 155§¶ (20) | −27 | |
| 8.0 | 228 (4) | 182 (11) | −20 | |
| 32.0 | 211 (7) | 111§¶ (26) | −43 | |
Note: TCP = tranylcypromine, FTCP = 4-fluorotranylcypromine, PLZ = phenelzine, AcPLZ = N2-acetylphenelzine, NA = not applicable.
↵* For zero doses of the 4 MAO inhibitors, the data are for clonidine alone (0.06 mg/kg).
↵† Calculated as (% interaction – % MAO inhibitor alone), where the percentages are calculated with respect to mean periods of immobility (and SEM) for control (vehicle). Mean period of immobility (and SEM) for controls, in seconds: TCP 231 (3), FTCP 223 (2), PLZ 222 (5) and AcPLZ 232 (3).
↵‡ F-test.
↵§ Significantly different from vehicle (p < 0.01) (Sidak’s test, n = 10).
↵¶ Significantly different from MAO inhibitor alone (p < 0.01) (Sidak’s test, n = 10).