Table 1

Effects of 4 monoamine oxidase (MAO) inhibitors on performance of mice in the forced swimming test

Dose, mg/kgMAO inhibitor; mean period of immobility (and SEM), s, and % of zero dose
Tranylcypromine4-FluorotranylcyprominePhenelzineN2-Acetylphenelzine
 0.0231 (3)100233 (2)100222 (5)100232 (3)100
 0.5204 (8)88228 (3)98NDND
 1.0223 (4)97226 (3)97227 (4)102237 (1)102
 2.0214 (12)93208 (17)89223 (5)100220 (10)95
 4.0191 (15)*83196 (23)84232 (3)104226 (5)97
 8.0170 (15)†74192 (13)82235 (2)106228 (4)98
16.0NDND224 (6)101228 (4)98
32.0NDND231 (4)104212 (7)‡91
p value§0.0020.1040.2500.050

  • Note: SEM = standard error of the mean, ND = not done.

  • ↵* Significantly different from zero dose (p = 0.04).

  • ↵† Significantly different from zero dose (p = 0.001).

  • ↵‡ Significantly different from zero dose (p = 0.05).

  • ↵§ F-test.