Olanzapine toxicity cases from the medical examiner of Alberta
| Case no. | Patient information | Clinical findings | ||||
|---|---|---|---|---|---|---|
| Age, yr | Sex | Olanzapine levels* | Other drugs detected | Cause of death, postmortem findings | Manner of death | |
| 12 | 50 | M | Ht blood 1170 | Bupropion | Acute multiple drug toxicity | Suicide |
| Liver 13000 | Fluoxetine | |||||
| Gastric 460 | Norfluoxetine | |||||
| 13 | 57 | F | F blood 970 | Paroxetine | Acute combined olanzapine and paroxetine toxicity | Suicide |
| Liver 18000 | Chlordiazepoxide | |||||
| Gastric 5500 | Demoxepam | |||||
| Nordiazepam | ||||||
| Flurazepam | ||||||
| 14 | 51 | F | IVC blood 660 | Codeine | Acute combined drug toxicity | Suicide |
| Liver 24000 | Acetaminophen | |||||
| Gastric 600 | Carbamazepine | |||||
| 15 | 42 | F | Cent blood 1700 | Codeine | Combined toxicity of olanzapine and codeine | Undetermined |
| Liver 27000 | Acetaminophen | |||||
| Gastric 1000 | ||||||
| 16 | 36 | F | Ht blood 4410 | No other drugs | Acute olanzapine toxicity | Suicide |
| Liver 47000 | ||||||
| Gastric 24000 | ||||||
| 17 | 28 | M | Ht blood 2000 | No other drugs | Olanzapine overdose | Suicide |
| Liver 56000 | ||||||
| Gastric 83000 | ||||||
Note: M = male; F = female; Ht = heart; F blood = femoral blood; IVC = inferior vena cava; Cent = central.
↵* Blood levels in ng/mL; liver levels in ng/g; gastric total contents in ng/mL.