Neuroimaging studies of the cerebellum in mood disorders
| Study | Subjects | Procedure | Unipolar | Bipolar |
|---|---|---|---|---|
| Structure | ||||
| DelBello et al (66) | 30 BPM, 15 HC | MRI | ⇓ V3 (BPM v. HC) | |
| Brambilla et al (67) | 22 BPV, 22 HC | MRI | ⇓ CbT (BPF v. HC) | |
| Shah et al (63) | 27 MDD, 36 HC | MRI | ⇓ CbV (MDD v. HC) | |
| Escalona et al (64) | 30 MDD, 35 HC | MRI | ⇓ CbT (MMD v. HC) | |
| Pillay et al (65) | 38 MDD, 20 HC | MRI | ⇔ CbT (MDD v. HC) | |
| Function: challenge | ||||
| Beauregard et al (68) | 7 MDD, 7 HC | fMRI | ⇓ L CbH (MDD v. HC) | |
| Smith et al (69) | 10 MDE, 8 HC | fMRI | ⇓ CbT (MDE v. HC) | |
| Liotti et al (70) | 10 MDE, 7 MDD, 8 HC | 15O PET | ⇓ CbT (MDE, MDD v. HC) ⇓ CbV (MDE v. MDD) | |
| Curtis et al (71) | 5 BPV, 5 SZ, 5 HC | fMRI | ⇑ CbV (BPV v. HC, SZ) | |
| Kruger et al (72) | 9 BPE, 11 BPD | 15O PET | ⇓ CbV (BPD v. BPE) ⇑ R Cb (BPE v. BPD) | |
| Function: rest | ||||
| Videbech et al (73) | 42 MDD, 47 HC | 15O PET | ⇑ CbT (MDD v. HC) | |
| Kimbrell et al (74) | 38 MDV, 37 HC | 18FDG PET | ⇑ R,L CbH (MDD v. HC) ⇑ CbV (MDD v. MDE) | |
| Ketter et al (75) | 43 BPV, 43 HC | 18FDG PET | ⇑ CbT (BPV v. HC) ⇔ Cb (BPD v. BPE) | |
| Osuch et al (76) | 25 MDD, 27 BPD | 18FDG PET | ⇑ L Cb (BPD v. MDD) | |
| Davies et al (77) | 7 MDD ⇒ MDE* | 99mTc SPECT | ⇑ R Cb (MDD v. MDE) | |
Note: BPD = biopolar disorder — depressed; BPE = bipolar disorder — euthymic; BPF = biopolar disorder — familial; BPM = bipolar disorder — manic; BPV = bipolar disorder — varied (all phases of illness); Cb = cerebellum; CbH = cerebellum hemisphere; CbT = cerebellum total; CbV = cerebellum vermis; FDG = fluorodeoxyglucose; fMRI = functional MRI; HC = healthy control; L = left; MDD = major depressive disorder — depressed; MDE = major depressive disorder — euthymic; MDV = major depressive disorder, various severities of depression; MRI = magnetic resonance imaging; PET = positron emission tomography; R = right; SZ = schizophrenia; SPECT = single-photon emission computed tomography; V3 = vermis area 3; ⇔ = no differences.
↵* Patients were scanned twice, before and after treatment of acute depression.