Table 1

Scores on assessment scales at baseline and after 6 and 12 weeks of treatment with loxapine, n = 24

Scale, time	Mean score (and SD)	Repeated ANOVA p value
Brief Psychiatric Rating Scale
Baseline	49.1 (7.6)	< 0.001^*
6 wk	41.8 (8.0)
12 wk	32.1 (8.2)
PANSS, modified
Baseline	41.6 (6.9)	< 0.001^*
6 wk	34.8 (7.1)
12 wk	26.2 (7.7)
PANSS, positive
Baseline	21.5 (3.8)	< 0.001^*
6 wk	17.8 (4.0)
12 wk	13.3 (4.2)
PANSS, negative
Baseline	24.1 (4.9)	< 0.001^*
6 wk	20.5 (4.7)
12 wk	14.9 (4.1)
PANSS, general
Baseline	45.0 (7.7)	< 0.001^*
6 wk	38.3 (7.2)
12 wk	30.0 (8.3)
PANSS, total
Baseline	90.7 (13.3)	< 0.001^*
6 wk	76.5 (14.2)
12 wk	58.3 (15.4)
Rajotte Scale
Baseline	31.8 (9.9)	< 0.001^*
6 wk	26.3 (6.6)
12 wk	22.1 (6.4)
Hamilton Anxiety Scale Baseline
6 wk	6.3 (3.4)	< 0.001^*
12 wk	3.7 (2.7)	< 0.001^*
Hamilton Depression Scale
Baseline	12.0 (3.0)	< 0.001^*
6 wk	8.6 (3.4)
12 wk	5.7 (4.1)
Quality of Life
Baseline	59.9 (23.4)	< 0.08
6 wk	52.9 (26.7)
12 wk	51.4 (26.2)
Clinical Global Impression
Baseline	4.1 (0.4)	< 0.001^*
6 wk	3.5 (0.6)
12 wk	2.2 (0.9)

Note: SD = standard deviation; ANOVA = analysis of variance; PANSS = Positive and Negative Symptoms Scale.
↵* Significant, p < 0.05.