Table 1

Agents studied for their neuroprotective properties in HIV infection

AgentProposed mechanism
PentoxyfilineInhibits TNF alpha
NimodipineDecreases intracellular calcium
Peptide TBlocks gp120 protein
MemantineNMDA antagonist
SelegilineProdopaminergic, antioxidant and antipoptotic
LexipafantPAF antagonist
  • NMDA = N-methyl-d-aspartate; PAF = platelet-activating factor; TNF = tumour necrosis factor.