The effect of oral SAMe administration on concentrations of SAMe and SAH measured 2 hours later in different brain regions, liver and blood
| Tissue | Dose of SAMe; mean* (and SE) concentration of SAH and SAMe | |||||||
|---|---|---|---|---|---|---|---|---|
| Control (no dose of SAMe) | SAMe, 100 mg/kg | SAMe, 200 mg/kg | SAMe, 400 mg/kg | |||||
| SAH | SAMe | SAH | SAMe | SAH | SAMe | SAH | SAMe | |
| Brain stem | 1.30 (0.15) | 10.3 (0.3)a | 1.24 (0.17) | 12.3 (0.5)b | 0.93 (0.08) | 12.3 (0.1)b | 1.10 (0.06) | 13.0 (0.2)b |
| Cerebellum | 2.16 (0.14)a | 12.9 (0.4) | 2.23 (0.16)a | 13.5 (0.6) | 1.73 (0.19) | 14.2 (0.2) | 1.35 (0.08)b | 14.5 (0.6) |
| Rest of brain | 1.32 (0.11) | 10.7 (0.3)a | 1.49 (0.13) | 12.0 (0.2)b | 1.26 (0.09) | 11.1 (0.2)a | 1.30 (0.06) | 11.6 (0.2) |
| Spinal cord | 1.37 (0.06) | 11.2 (0.8) | 1.40 (0.06) | 12.1 (1.2) | 1.50 (0.08) | 9.78 (0.50) | 1.71 (0.17) | 12.4 (1.0) |
| Liver | 9.19 (0.23) | 25.4 (2.0)a | 9.54 (0.30) | 30.8 (1.8) | 9.57 (0.33) | 33.4 (0.9) | 10.3 (0.4) | 37.8 (2.3)b |
| Blood | ND | 1.83 (0.07)a | ND | 1.86 (0.05)a | ND | 2.47 (0.08)b | ND | 2.52 (0.20)b |
Note: ND = not detected; SAH = S-adenosylhomocysteine; SAMe = S-adenosylmethionine; SE = standard error of the mean.
↵* Values are the mean of 5 measurements for controls and 7 measurements for the other groups (and SE) in μg/g tissue and μg/mL of blood.
↵a,b Superscripts refer to comparisons between groups receiving different doses, for the same compound and brain area, using Scheffé tests. Means for each variable having no superscript are not significantly different (p > 0.05) from any of the other groups. Means with the same superscript do not differ significantly, but means for which there is no superscript in common differ significantly (p < 0.05).