Interaction between cytochrome P450 (CYP) enzymes and clozapine
| Enzyme | Involved in metabolism of clozapine | Inhibited by clozapine; in vitro data only | ||
|---|---|---|---|---|
| In vitro | In vivo | |||
| Case reports | Case series | |||
| CYP1A1 | − | |||
| CYP1A2 | + | + | + | − |
| CYP2C8 | +/− | |||
| CYP2C9 | + (NC) | + (NC) | ||
| CYP2C19 | + | − | ||
| CYP2D6 | +/− | +/− | +/− | + (NC) |
| CYP2E1 | − | |||
| CYP3A4 | + | + | − | − |
Note: All studies were performed on humans or human tissue. + = data support role; − = data do not support role; +/− = data are contradictory; NC = likely not clinically relevant. Space left blank if no data available. The above footnotes apply to all tables in this article.