Distribution of [3H]-epibatidine plus 150 nmol/L cytisine binding sites in selected brain regions of 15-month-old WKY and SHR rats
| Brain area | Rat strain; mean (and SEM) binding, nCi bound [3H]/mg wet tissue, n = 5–6 | |
|---|---|---|
| WKY | SHR | |
| Cerebral cortex | 0.10 (0.02) | 0.09 (0.02) |
| Habenular nucleus, medial | 11.29 (0.02) | 11.10 (0.18) |
| Geniculate nuclei | ||
| Dorsal lateral | 0.39 (0.04) | 0.36 (0.04) |
| Ventral lateral | 0.38 (0.04) | 0.33 (0.04) |
| Medial | 0.13 (0.01) | 0.13 (0.01) |
| Superior colliculus | ||
| Superficial gray layer* | 1.33 (0.06) | 0.94 (0.06) |
| Interpeduncular nucleus | 11.11 (0.05) | 11.14 (0.07) |
| Fasciculus retroflexus | 1.06 (0.05) | 0.92 (0.08) |
Whole brains were sectioned from the prefrontal cortex through the pons.
↵* Significant difference between phenotypes (SHR > WKY, p < 0.01).