Distribution of [3H]-pirenzipine binding sites in selected brain regions of 15-month-old Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats
| Brain area | Rat strain; mean (and SEM) binding, nCi bound [3H]/mg wet tissue, n = 5–6 | |
|---|---|---|
| WKY | SHR | |
| Amygdaloid nuc., basolateral | 10.51 (0.18) | 10.42 (0.11) |
| Amygdaloid nuc., central | 4.75 (0.22) | 4.43 (0.17) |
| Accumbens nuc., core | 11.04 (0.14) | 10.85 (0.30) |
| Accumbens nuc., shell | 10.36 (0.22) | 10.36 (0.25) |
| Caudate putamen | 9.04 (0.16) | 9.62 (0.23) |
| Cerebral cortex | ||
| Auditory | 9.49 (0.32) | 10.22 (0.27) |
| Cingulate area 1 | 8.85 (0.22) | 8.92 (0.26) |
| Cingulate area 2 | 9.08 (0.23) | 8.71 (0.30) |
| Entorhinal, lateral | 9.75 (0.34) | 10.39 (0.30) |
| Frontal association | 9.56 (0.13) | 10.24 (0.16) |
| Medial* | 8.72 (0.16) | 9.48 (0.12) |
| Outer | 10.11 (0.13) | 10.63 (0.11) |
| Infralimbic | 9.91 (0.14) | 10.32 (0.08) |
| Insular* | 9.63 (0.15) | 10.28 (0.10) |
| Prefrontal* | 9.24 (0.15) | 10.10 (0.14) |
| Medial* | 8.88 (0.16) | 9.75 (0.17) |
| Outer | 9.94 (0.13) | 10.52 (0.17) |
| Prelimbic | 9.62 (0.11) | 10.05 (1.34) |
| Motor area 1 | 8.43 (0.18) | 9.16 (0.26) |
| Motor area 2 | 8.93 (0.15) | 9.50 (0.25) |
| Orbital* | 9.17 (0.11) | 10.04 (0.20) |
| Parietal entire | 9.26 (0.33) | 9.89 (0.27) |
| Layer I | 9.93 (0.35) | 10.50 (0.28) |
| Layer II–VI | 9.00 (0.35) | 9.75 (0.17) |
| Piriform | 9.30 (0.14) | 9.43 (0.33) |
| Retrosplenial | 4.60 (0.22) | 5.12 (0.29) |
| Somatosensory | 7.49 (0.13) | 8.11 (0.29) |
| Temporal | 8.43 (0.20) | 8.80 (0.16) |
| Layer I | 9.42 (0.20) | 9.76 (0.29) |
| Layer II–VI | 7.89 (0.19) | 8.16 (0.13) |
| Visual | 9.32 (0.35) | 10.00 (0.27) |
| Anterior olfactory nuc. | 9.95 (0.11) | 10.42 (0.10) |
| Dentate gyrus inner blade | ||
| Anterior | 11.62 (0.20) | 11.20 (0.14) |
| Posterior | 10.65 (0.21) | 10.81 (0.17) |
| Dentate gyrus outer blade | ||
| Anterior | 11.23 (0.16) | 11.32 (0.22) |
| Posterior | 10.94 (0.18) | 11.18 (0.11) |
| Dentate polymorph layer | ||
| Anterior | 9.63 (0.16) | 10.05 (0.13) |
| Posterior* | 9.54 (0.19) | 10.20 (0.11) |
| Hippocampal formation | ||
| CA1 anterior | 11.97 (0.13) | 11.83 (0.21) |
| CA1 posterior | 10.90 (0.14) | 11.15 (0.13) |
| CA2 and 3 anterior | 8.35 (0.15) | 8.32 (0.22) |
| CA2 and 3 posterior | 9.14 (0.25) | 9.48 (0.25) |
| Indusium griseum | 8.96 (0.27) | 8.99 (0.48) |
| Olfactory tubercle | 9.74 (0.20) | 10.13 (0.22) |
| Subiculum | 5.64 (0.23) | 5.96 (0.19) |
| Septal nuc., lateral | 0.70 (0.09) | 1.40 (0.13) |
| Dorsal peduncular nuc. | 9.91 (0.18) | 10.48 (0.10) |
| Thalamus | 1.00 (0.08) | 0.98 (0.14) |
Whole brains were sectioned from the prefrontal cortex through the pons.
↵* Significant difference between phenotypes (SHR > WKY, p < 0.01).