Table 2

Comparisons of region of interest grey matter volume between healthy controls with and without a family history of MDD and patients with MDD

Patient group comparison; region of interest	p value (FWE– corrected)	κ	T	MNI coordinate
Patient group comparison; region of interest	p value (FWE– corrected)	κ	T	x	y	z
Interaction
Left hippocampus	0.039	137	3.23	−30	−9	−23
Left hippocampus	0.044	27	3.18	−32	−26	−16
Right hippocampus	0.05	84	3.12	24	−22	−9
Right caudate	0.05	363	3.12	−17	21	3
HC-FHN > HC-FHP
Right hippocampus	0.042	597	3.20	26	−41	−1
Right dorsolateral prefrontal cortex	0.031	128	3.32	30	13	11
HC-FHN < HC-FHP
No voxels	NS	—	—	—	—	—
HC-FHN > MDD
Left dorsomedial prefrontal cortex	0.011	626	3.71	−2	46	23
Left anterior cingulate cortex	0.036	484	3.27	6	45	14
Left caudate	0.035	51	3.28	−28	4	11
Right caudate	0.047	63	3.15	28	16	11
HC-FHN < MDD
No voxels	NS	—	—	—	—	—
HC-FHP > MDD
Right anterior cingulate cortex	0.022	369	3.45	4	44	13
Right dorsomedial prefrontal cortex	0.049	317	3.14	8	57	20
HC-FHP < MDD
Right hippocampus	0.017	1156	3.54	25	−13	−15

FWE = family-wise error; HC-FHN = healthy controls without a family history of depression; HC-FHP = healthy controls with a family history of depression; MDD = major depressive disorder; MNI = Montreal Neurological Institute; NS = not significant.