Malison et al166 | [123I]β-CIT SPECT | 15, 15 | MDD and/or comorbid disorders | 6 medication naive, 9 medication free for 3 wk | Lower BP in brainstem |
Ichimiya et al46 | [11C](+)McN5652 PET | 7,* 15 | MDD only (pooled with BD only) | All medication free for > 6 wk | ↑ 5-HTT BP in thalamus; no change in midbrain in pool of MDD and BD subjects |
Meyer et al47 | [11C]DASB PET | 20, 20 | MDD only | All medication free for > 3 mo and 14 also antidepressant naive | No change in 5-HTT BP in MDE; in MDE with severe pessimism, greater 5-HTT BP in all regions except midbrain |
Newberg et al167 | [123I]ADAM SPECT | 7, 6 | MDD only | All medication free for > 2 wk, 2 antidepressant naive | No change in 5-HTT BP in thalamus and striatum; lower 5-HTT BP in midbrain |
Parsey et al168 | [11C](+)McN5652 PET | 25, 43 | MDD, n = 19 with comorbid anxiety disorders | All potentially exposed to benzodiazepines. All antidepressant free for > 2 wk; 12 antidepressant naive | No change in putamen, thalamus, hippocampus, or anterior cingulate ↓ 5-HTT BP in midbrain and amygdala† |
Herold et al169 | [123I]ADAM SPECT | 21, 13 | MDD only | All medication free for > 2mo | Trend toward greater midbrain 5-HTT BP |