– 100:1 greater affinity for 5-HT_2A receptors over 5-HT_2C receptors, and a 1:10 to 1:50 greater affinity of 5-HT_2A receptors over D₂ receptors.111 Since D₂ receptors are 10-fold less dense in human cortex82^–84^,112 the combined relative effects of affinity and density correspond to an estimate that at least 99% of the specific binding signal in cortex is attributable to 5-HT_2A receptors.

– No effect of the D₂ antagonist amisulpride on [¹⁸F] setoperone binding in human cortex113

– 5-HT₂ antagonists fully block specific binding in animal and human cortex106^,107^,114^,115

– Not selective in striatum where D₂ receptor density is high107