Activation of regions showing significant* grey matter reduction in patients with unipolar depression compared with healthy control subjects
| Region | Cluster size | Talairach coordinates | t value | ||
|---|---|---|---|---|---|
| x | y | z | |||
| Amygdala / hippocampal formation | 1183 | 16 | −9 | −24 | 4.97 |
| Orbitofrontal cortex (gyrus rectus, BA 11) | 850 | 2 | −41 | −28 | 4.43 |
| Middle frontal gyrus (BA 8/9) | 257 | −30 | 24 | 42 | 3.81 |
| Subgenual cortex (BA 25) / gyrus rectus (BA 11) | 276 | −1 | 9 | −21 | 3.79 |
BA = Brodmann’s area.
↵* p < 0.001, cluster size > 192.