Table 3

Summary of group differences in cortical volume and cerebral grey matter

Parameter statistics*Covariate statistics*
NTC v. PTSD NTC v. TC TC v. PTSD Age ICV Hemisphere
Imaging; brain regionF2,44p valuet44p valuet44p valuet44p valueF1,44p valueF1,44p valueF1,48p value
Bilateral isthmus of the cingulate3.980.025−2.590.013−2.480.017−0.040.9714.66< 0.00141.65< 0.0011.120.30
Bilateral lateral orbitofrontal cortex2.380.10−1.490.14−2.170.0350.840.419.020.00413.57< 0.001123.95< 0.001
Left rostral middle frontal cortex4.120.022−2.680.010−0.840.40−2.030.0488.330.0066.820.012
Right inferior parietal cortex4.570.016−3.020.004−1.900.06−< 0.001
VBM grey matter volumes (extracted with MarsBaR)
Left isthmus of the cingulate5.450.008−3.260.002−2.410.020−0.870.393.690.0616.46< 0.001
Right inferior parietal cortex6.690.003−3.65< 0.001−2.030.049−1.750.0912.93< 0.0019.620.003
Left rostral anterior cingulate cortex4.750.013−3.030.004−2.300.026−0.750.467.340.01010.590.002
Right rostral anterior cingulate cortex6.010.005−3.240.002−2.960.005−0.220.833.290.0812.200.001
  • ICV = intracranial volume; NTC = nontraumatized control group; PTSD = posttraumatic stress disorder; TC = traumatized control group; VBM = voxel-based morphometry.

  • * All tests were 2-tailed, with p < 0.001 indicating a significant group difference.