Group; mean (SD) [range]* | ||
---|---|---|
Characteristic | Huntington disease | Control |
Number | 39 | 40 |
Sex, male:female | 16:23 | 19:21 |
Age, yr | 47.9 (9.5) [28–69] | 46.3 (7.1) [25–67] |
CAG expansion | 45.4 (4.5) [39–63] | NA |
Toxic load | 435 (109) [224–825] | NA |
Age at onset of motor symptoms, yr | 42.4 (9.4) [22–61] | NA |
Age at onset of psychiatric symptoms, yr | 41.4 (9.3) [18–63] | NA |
UHDRS | ||
Motor score | 43.5 (19.7) [7–88] | NA |
Functional capacity | 7.6 (2.7) [2–12] | NA |
Independence scale, % | 70.8 (13.5) [50–90] | NA |
Cognitive score | 151 (59) [60–346] | NA |
Symptoms of depression at time of evaluation, no. (%) | 21 (53.8) | 0 |
History of depressive episode, no. (%) | 30 (76.9) | 0 |
HAM-D score | 15.7 (8.5) [3–37] | 1.0 (2.1) [0–8] |
HAM-D* score | 12.6 (8.9) [1–34] | 0.8 (1.9) [0–6] |
BDI score | 11.9 (10.1) [0–39] | 2.0 (2.8) [0–8] |
BDI = Beck Depression Inventory;18 CAG expansion = expansion of the trinucleotide repeat, cytosine–adenine–guanine on chromosome 4p16.3; HAM-D = Hamilton Rating Scale for Depression;19 HAM-D* = HAM-D with exclusion of items 7–9, 13 and 16; NA = not applicable; SD = standard deviation; Toxic load = (CAG-exp − 35.5) × age; UHDRS = Unified Huntington’s Disease Rating Scale.20
↵* Unless otherwise indicated.