Table 1

Regions of significant brain volume reduction in the combined PTSD and major depression groups compared with controls^*

Foci of activation	Brodmann area	MNI coordinate			z score	Cluster size
Foci of activation	Brodmann area	x	y	z	z score	Cluster size
Middle cingulate cortex	6	2	−7	41	4.23	780
Superior frontal gyrus/medial frontal gyrus/anterior cingulate gyrus	8, 9, 10, 32	3	54	30	4.12	605
Right middle frontal gyrus/superior frontal gyrus	8, 9, 10	34	25	52	4.07	1260
Right angular gyrus^†	39	55	−55	37	3.92	304
Right superior frontal gyrus^†	6	6	−7	77	3.88	209
Right postcentral gyrus^†	1	50	−32	58	3.87	362
Left superior parietal lobule/inferior parietal lobule^†	7	−21	−70	50	3.86	371
Left precentral gyrus^†	6	−19	−21	63	3.85	366
Left ventral inferior frontal gyrus/orbitofrontal cortex^†	47	−35	24	−26	3.76	319
Right supramarginal gyrus^†	40	45	−38	32	3.68	183
Left parietal operculum^†	40/3b	−66	−3	6	3.63	178
Left anterior cingulate cortex^‡	32	−6	46	7	3.53	184

MNI = Montreal Neurological Institute; PTSD = posttraumatic stress disorder.
↵* Significant at p < 0.05, family wise error–corrected, whole-brain cluster level–corrected.
↵† Significant at the cluster level, but does not survive whole-brain correction.
↵‡ Small volume corrections significant at p < 0.05.