Table 3

Relevant pharmacogenetic association studies that focused on TPH1 and TPH2

Study	Gene	Drug	Results	Quality (0–31)	Sample size
Tsai et al.115	TPH2	Fluoxetine, citalopram	rs2171363 heterozygote ↑ response	20	508
Illi et al.116	TPH1	Fluoxetine, paroxetine,	No association for rs1800532 (TPH1) and rs1386494 (TPH2)	13	86
	TPH2	citalopram
Peters et al.117	TPH1	Fluoxetine, citalopram	No association with citalopram response	17	2049
	TPH2
Tzvetkov et al.118	TPH2	Various antidepressants	rs10897346 and rs1487278 ↑ response	13	253
Kato et al.84	TPH1	Paroxetine, fluvoxamine	No association with treatment response and side effects	22	100
Hong et al.83	TPH1	Fluoxetine	No association	15	224
Ham et al.78	TPH1	Citalopram	rs1800532 A allele ↓ remission	18	105
Ham et al.82	TPH1	Various	No association	18	93
Serretti et al.119	TPH1	Various	No association	22	185
Serretti et al.120	TPH1	Fluvoxamine, paroxetine	No association	22	221
Peters et al.85	TPH1	Fluoxetine	7180T/G, -7065T/C, -5806T/G (TPH1) and rs1843809,	19	96
	TPH2		rs1386492, rs1487276 (TPH2) ↑ response
Takahashi et al.121	TPH1	Fluvoxamine	No association with iatrogenic nausea	21	66
Yoshida et al.81	TPH1	Fluvoxamine	No association	15	66
Serretti et al.77	TPH1	Fluvoxamine	rs1800532 A/A genotype ↓ response	22	217
Serretti et al.76	TPH1	Paroxetine	rs1800532 A/A and A/C genotypes ↓ response	23	119