Table 8

Relevant pharmacogenetic association studies that focused on 5-HT_2A

Study	Gene	Drug	Results	Quality (0–31)	Sample size
Uher et al.229	5-HT_2A	Escitalopram, nortriptyline	G allele rs9316233 and A allele rs2224721 ↑ response to escitalopram	19	760
Illi et al.116	5-HT_2A	Fluoxetine, paroxetine, citalopram	No association	13	86
Perlis et al.134	5-HT_2A	Duloxetine	rs9534505, rs1923884, rs2760351 ↑ association	13	102
Peters et al.117	5-HT_2A	Fluoxetine, citalopram	rs1923884 ↑ remission rs7997012 ↑ remission and response	17	2049
Wilkie et al.179	5-HT_2A	Paroxetine	rs6314 ↑ remission and response	11	166
Horstmann et al.261	5-HT_2A	Various	rs7997012 G allele ↑ response	3	300
Tanaka et al.217	5-HT_2A	Paroxetine	No association	15	72
Kang et al.262	5-HT_2A	Mirtazapine	No association	17	101
Bishop et al.263	5-HT_2A	Various SSRIs	rs6311 G/G genotype ↑ iatrogenic sexual dysfunction	14	81
McMahon et al.260	5-HT_2A	Citalopram	rs799701 ↑ response	19	1297
Hong et al.83	5-HT_2A	Fluoxetine	No association	15	224
Suzuki et al.52	5-HT_2A	Fluvoxamine	In CYP2D6 PM, rs6311 A/G and G/G genotypes ↑ gastrointestinal side effects	18	96
Kato et al.190	5-HT_2A	Fluoxetine, paroxetine	rs6311 G/G genotype ↑ response and nausea in paroxetine treatment	17	100
Choi et al.257	5-HT_2A	Citalopram	rs6311 A/G and GG genotypes ↑ response	17	71
Yoshida et al.185	5-HT_2A	Milnacipran	No association	17	80
Peters et al.85	5-HT_2A	Fluoxetine	rs1923882, rs6314, rs3125 ↑ response	19	96
Murphy et al.57	5-HT_2A	Paroxetine, mirtazapine	rs6313 C/C genotype ↑ paroxetine-induced side effects	18	122
Yoshida et al.155	5-HT_2A	Fluvoxamine	No association with iatrogenic nausea	16	54
Cusin et al.153	5-HT_2A	Fluvoxamine, paroxetine	rs6313 C allele ↑ response	22	217
Sato et al.258	5-HT_2A	Fluvoxamine	No association	15	54
Minov et al.176	5-HT_2A	Various antidepressants	rs6313 C allele ↑response	9	104

↑= positive association; ↓ = negative association; PM = poor metabolizer; SSRI = selective serotonin reuptake inhibitor.