Table 8

Relevant pharmacogenetic association studies that focused on 5-HT2A

StudyGeneDrugResultsQuality (0–31)Sample size
Uher et al. (229)5-HT2AEscitalopram, nortriptylineG allele rs9316233 and A allele rs2224721 ↑ response to escitalopram19760
Illi et al. (116)5-HT2AFluoxetine, paroxetine, citalopramNo association1386
Perlis et al. (134)5-HT2ADuloxetiners9534505, rs1923884, rs2760351 ↑ association13102
Peters et al. (117)5-HT2AFluoxetine, citalopramrs1923884 ↑ remission
rs7997012 ↑ remission and response		172049
Wilkie et al. (179)5-HT2AParoxetiners6314 ↑ remission and response11166
Horstmann et al. (261)5-HT2AVariousrs7997012 G allele ↑ response3300
Tanaka et al. (217)5-HT2AParoxetineNo association1572
Kang et al. (262)5-HT2AMirtazapineNo association17101
Bishop et al. (263)5-HT2AVarious SSRIsrs6311 G/G genotype ↑ iatrogenic sexual dysfunction1481
McMahon et al. (260)5-HT2ACitalopramrs799701 ↑ response191297
Hong et al. (83)5-HT2AFluoxetineNo association15224
Suzuki et al. (52)5-HT2AFluvoxamineIn CYP2D6 PM, rs6311 A/G and G/G genotypes ↑ gastrointestinal side effects1896
Kato et al. (190)5-HT2AFluoxetine, paroxetiners6311 G/G genotype ↑ response and nausea in paroxetine treatment17100
Choi et al. (257)5-HT2ACitalopramrs6311 A/G and GG genotypes ↑ response1771
Yoshida et al. (185)5-HT2AMilnacipranNo association1780
Peters et al. (85)5-HT2AFluoxetiners1923882, rs6314, rs3125 ↑ response1996
Murphy et al. (57)5-HT2AParoxetine, mirtazapiners6313 C/C genotype ↑ paroxetine-induced side effects18122
Yoshida et al. (155)5-HT2AFluvoxamineNo association with iatrogenic nausea1654
Cusin et al. (153)5-HT2AFluvoxamine, paroxetiners6313 C allele ↑ response22217
Sato et al. (258)5-HT2AFluvoxamineNo association1554
Minov et al. (176)5-HT2AVarious antidepressantsrs6313 C allele ↑response9104

  • ↑= positive association; ↓ = negative association; PM = poor metabolizer; SSRI = selective serotonin reuptake inhibitor.