Table 4

Relevant pharmacogenetic association studies that focused on COMT

Study	Gene	Drug	Results	Quality (0–31)	Sample size
Benedetti et al.132	COMT	Paroxetine	Rs4680 Met/Met ↑ response, Met/Val ↑↓ response, Val/Val ↓ response	17	55
Leuchter et al.133	COMT	Placebo	Rs4680 Met/Met ↓ placebo response	15	132
Tsai et al.130	COMT	Fluoxetine	Males rs4680 Met carriers ↑ response	16	334
Perlis et al.134	COMT	Duloxetine	rs165599 GG, rs165774 GG, rs174696 CC ↑ response	13	102
Baune et al.131	COMT	Various	Rs4680 Met/Met ↑ response	18	256
Yoshida et al.129	COMT	Milnacipram	Rs4680 Met/Met ↑ faster therapeutic effect	18	81
Hu et al.135	COMT	Bupropion	rs6277 TC genotype ↑ weight gain No association with body mass index or weight change	16	283
Arias et al.122	COMT	Various	Small effect on citalopram treatment result	18	346
Szegedi et al.128	COMT	Mirtazapine, paroxetine	Rs4680 ↑ mirtazapine response	13	102