Table 7

Relevant pharmacogenetic association studies that focused on 5-HT_1A

Study	Gene	Drug	Results	Quality (0–31)	Sample size
Illi et al. 116	5-HT_1A	Fluoxetine, paroxetine, citalopram	No association	13	86
Kato et al.239	5-HT_1A	SSRIs/SNRIs	rs10042486 C/C, rs6295 G/G, rs1364043 T/T genotypes ↑ response	20	137
Baune et al.245	5-HT_1A	Various	In melancholic subtype rs6295 CC genotype ↓ response	20	340
Levin et al.243	5-HT_1A	SSRIs	No association	6	130
Yu et al.244	5-HT_1A	Fluoxetine	In female rs6295 C/C ↑ genotype response	13	222
Hong et al.83	5-HT_1A	Fluoxetine	rs6295 C/C genotype ↑ response	15	224
Suzuki et al.52	5-HT_1A	Fluvoxamine	No association	18	96
Parsey et al.242	5-HT_1A	Various antidepressants, ECT	rs6295 C/G and GG genotype ↓ response	12	22
Arias et al.222	5-HT_1A	Citalopram	rs6295 GG genotype + HTTLPR ss ↓ response	18	130
Serretti et al.240	5-HT_1A	Fluvoxamine	rs6295 C/C genotype ↑ response	24	262
Suzuki et al.246	5-HT_1A	Fluvoxamine	rs1800042 Gly/Gly genotype ↓ response	17	52
Peters et al.85	5-HT_1A	Fluoxetine	No association	19	96
Lemonde et al.241	5-HT_1A	Fluoxetine + pindolol Nefazodone+pindolol Flibanserin	rs6295 G allele ↓ response to flibanserin	14	107

↑ = positive association; ↓ = negative association; ECT = electroconvulsive therapy; SNRI = serotonin–norepinephrine reuptake inhibitor; SSRI = selective serotonin reuptake inhibitor.