Table 2

Relevant pharmacogenetic association studies that focused on P-glycoprotein

Study	Gene	Drug	Results	Quality (0–31)	Sample size
Gex-Fabry et al.67	P-glycoprotein	Paroxetine	ABCB1 genotype ↑ response (61A>G)	18	71
Kato et al.68	P-glycoprotein	Paroxetine	rs1045642, rs2032582, rs1128503 ↓ response rs2032582 ↑ response (T/T, T/A or A/A)	20	68
Mihaljevic Peles et al.69	P-glycoprotein	Paroxetine	No association	22	127
Nikisch et al.70	P-glycoprotein	Citalopram	rs2032582 GG/GT genotype ↑ response	5	15
Peters et al.50	P-glycoprotein	Citalopram	No association with response or tolerance	25	1953
Uhr et al.59	P-glycoprotein	Various	C allele (rs2032583) and T allele (rs2235015) ↑ response when antidepressant used a target of the P-glycoprotein	16	297
Fukui et al.71	P-glycoprotein	Fluvoxamine	rs1045642 T allele ↑ fluvoxamine plasma levels	13	62
Laika et al.72	P-glycoprotein	Amitriptyline	No association	14	50
Roberts et al.73	P-glycoprotein	Nortriptyline	rs1045642 C allele ↑ postural hypotension	17	160