Hippocampus and amygdala volumes in patients with major depression and participants in the control group at baseline and at 3-year follow-up
| Volume, mL; patient status* | Group; mean (and SD) | |||||
|---|---|---|---|---|---|---|
| Patients, n = 30 | Controls, n = 30 | |||||
| Baseline | Follow-up | Change [95% CI] | Baseline | Follow-up | Change [95% CI] | |
| Hippocampus | — | — | ||||
| Left total | 3.71 (0.34) | 3.78 (0.38) | 3.72 (0.37) | 3.76 (0.40) | 0.035 (0.24) [−0.053 to 0.12] | |
| In remission | 3.76 (0.37) | 3.86 (0.31) | 0.075 (0.24) [−0.018 to 0.17] | — | — | |
| Nonremitted | 3.65 (0.29) | 3.68 (0.45) | — | — | ||
| Right total | 3.85 (0.34) | 3.85 (0.33) | 3.82 (0.47) | 3.83 (0.42) | 0.01 (0.27) [−0.09 to 0.11] | |
| In remission | 3.76 (0.37) | 3.94 (0.25) | 0.006 (0.29) [−0.10 to 0.11] | — | — | |
| Nonremitted | 3.78 (0.33) | 3.73 (0.39) | — | — | ||
| Amygdala | ||||||
| Left total | 1.47 (0.25) | 1.43 (0.27) | 1.39 (0.21) | 1.37 (0.22) | −0.02 (0.25) [−0.12 to 0.07] | |
| In remission | 1.47 (0.19) | 1.48 (0.28) | −0.02 (0.25) [−0.12 to 0.07] | — | — | |
| Nonremitted | 1.48 (0.32) | 1.37 (0.26) | — | — | ||
| Right total | 1.56 (0.30) | 1.54 (0.27) | 1.45 (0.28) | 1.49 (0.25) | −0.03 (0.22) [−0.11 to 0.06] | |
| In remission | 1.59 (0.30) | 1.61 (0.30) | −0.04 (0.23) [−0.13 to 0.05] | — | — | |
| Nonremitted | 1.53 (0.31) | 1.45 (0.22) | — | — | ||
CI = confidence interval; SD = standard deviation.
↵* We considered 17 patients to be in remission and 13 patients to be nonremitted.