Table 3

Regions displaying high discrimination weights between patients with MDD and controls for cortical thickness measures

	Talairach coordinates

Brain region^*	x	y	z	W
MDD > control
Left hemisphere
Lateral occipital gyrus	−18	−100	3	5.32
Posterior cingulate gyrus	−6	−30	27	5.93
Superior frontal gyrus	−22	9	49	4.59
Inferiorparietal lobular	−36	−75	38	6.27
Supramarginal gyrus	−56	−48	35	4.29
Precentral gyrus	−55	2	33	4.12
Postcentral gyrus	−64	−11	18	5.63
Middle temporal gyrus	−60	−13	−23	6.75
Superior temporal gyrus	−58	−5	−2	4.05
Right hemisphere
Rostral middle frontal	43	38	23	11.01
Pars opercularis	55	24	14	5.47
Caudalmiddlefrontal gyrus	41	18	47	4.45
Precentral lobule	44	−10	42	7.00
Temporal pole	44	7	−37	9.56
Pars orbitalis	39	53	−8	6.06
Lateral occipital gyrus	17	−94	17	5.45
pericalcarine	16	−75	8	5.90
Isthmus cingulate gyrus	8	−48	12	8.17
Anterior cingulate gyrus	8	32	11	7.79
Insular lobe	37	−15	2	4.57
Paracentral lobule	8	−29	51	4.78
Control > MDD
Left hemisphere
Precentral lobule	−16	−22	73	−7.10
Insular lobe	−37	3	0	−6.37
Superior temporal sulcus	−42	−53	19	−5.41
Precuneus	−8	−49	52	−6.23
Paracentral lobule	−3	−36	67	−4.96
Caudal anterior cingulate gyrus	−4	6	28	−8.87
Lingual gyrus	−23	−62	−10	−6.09
Fusiform gyrus	−34	−47	−10	−10.01
Lateral occipital gyrus	−39	−81	−14	−9.27
Rostral middle frontal gyrus	−28	54	−11	−7.74
Right hemisphere
Precuneus	10	−61	46	−10.19
Insular lobe	36	14	−2	−5.23
Superior temporal gyrus	63	−7	−2	−7.20
Entorhinal cortex	25	−9	−31	−7.05
Lingual gyrus	20	−75	−10	−7.28
Paracentral lobular	13	−45	73	−5.52
Supramarginal gyrus	59	−25	30	−7.35
Inferior temporal sulcus	60	−41	−13	−7.58
Lateral occipital gyrus	41	−83	4	−4.43
Superior frontal gyrus	14	62	12	−4.64

MDD = major depressive disorder; W = weight vector value.
↵* These regions were identified by setting the threshold at greater than 30% of the maximum value of the discrimination map. Positive weight vector values represent MDD > control; negative weight vector value represent control > MDD.