Table 2

Average fractional anisotropy measurements and Montreal Neurological Institute coordinates for participants with MCI and no history of depression (MCI), MCI and a history of major depression (MCI-MD) and healthy controls

Group; fractional anisotropy, mean ± SD
Anatomic regionMNI coordinates (x, y, z)MCI-MD, n = 36MCI, n = 30Control, n = 22p value*
MCI v. controls
Corpus callosum
 Genu103, 151, 910.6447 ± 0.06160.6898 ± 0.06240.035
 Body103, 138, 990.6056 ± 0.05880.6689 ± 0.05280.034
 Splenium104, 90, 980.8263 ± 0.04620.8399 ± 0.05110.033
Left posterior thalamic radiation124, 75, 830.5236 ± 0.07110.5458 ± 0.11340.034
Anterior corona radiata
 Left113, 155, 730.5651 ± 0.08760.6076 ± 0.08820.044
 Right65, 155, 730.5336 ± 0.08200.5597 ± 0.06150.041
Posterior corona radiata
 Left116, 98, 990.5283 ± 0.05670.5358 ± 0.04780.034
 Right65, 98, 990.5262 ± 0.07260.5534 ± 0.08470.047
Superior corona radiata
 Left116, 109, 1030.4928 ± 0.04520.5111 ± 0.05100.030
 Right63, 109, 1030.4898 ± 0.04980.5184 ± 0.02970.033
Superior longitudinal fasciculus
 Left132, 77, 800.5779 ± 0.07190.5921 ± 0.08550.033
 Right47, 77, 800.6461 ± 0.05990.6669 ± 0.08400.048
MCI-MD v. controls
Corpus callosum
 Genu103,151, 910.6373 ± 0.09210.6898 ± 0.06240.020
 Body103,138, 990.6240 ± 0.08520.6689 ± 0.05280.020
 Splenium73, 88, 980.7693 ± 0.08080.7838 ± 0.05860.028
Posterior thalamic radiation
 Left124, 65, 790.4958 ± 0.08230.5327 ± 0.09920.027
 Right56, 65, 790.5020 ± 0.09980.5163 ± 0.09970.024
Anterior corona radiata
 Left112, 153, 730.6042 ± 0.12200.6547 ± 0.10510.025
 Right66, 153, 730.5522 ± 0.10700.6070 ± 0.07890.022
Posterior corona radiata
 Left108, 85, 1040.4317 ± 0.08520.4644 ± 0.08940.029
 Right64, 85, 1040.4062 ± 0.07770.4430 ± 0.06290.022
Superior corona radiata
 Left118,115, 960.5600 ± 0.05850.5753 ± 0.05240.025
 Right60,115, 960.5414 ± 0.07480.5682 ± 0.04360.040
Superior longitudinal fasciculus
 Left131, 75, 800.5616 ± 0.09420.5845 ± 0.05800.031
 Right54, 75, 800.5349 ± 0.10770.5573 ± 0.09230.026
Uncinate fasciculus
 Left125, 125, 580.6099 ± 0.08200.6345 ± 0.07560.035
 Right57, 131, 600.6604 ± 0.07100.6831 ± 0.07300.028
Fornix
 Left120, 102, 660.6189 ± 0.08820.6196 ± 0.10040.025
 Right59, 102, 660.5686 ± 0.08900.6036 ± 0.10760.035
Sagittal striatum
 Left129, 84, 650.5385 ± 0.07110.6017 ± 0.07540.023
 Right50, 84, 650.5910 ± 0.07520.6417 ± 0.07610.023
External capsule
 Right55, 121, 620.5384 ± 0.07350.5688 ± 0.06660.023
 Left124, 121, 620.6115 ± 0.10230.6449 ± 0.10940.035
Internal capsule
 Right75, 134, 790.6315 ± 0.07700.6866 ± 0.06960.023
 Left105, 134, 790.6188 ± 0.10570.6724 ± 0.09270.023
Right cingulum65, 99, 540.5214 ± 0.09650.5805 ± 0.06440.046
  • MCI = mild cognitive impairment; MD = major depression; MNI = Montreal Neurological Institute; SD = standard deviation.

  • * Tract-based spatial statistics.