Results of the conjunction and interaction analyses for recognition of social information (i.e., old social pictures v. social new pictures)*
| Talairach coordinates | |||||
|---|---|---|---|---|---|
| Analysis; brain region | x | y | z | t value | Cluster size |
| Conjunction† | |||||
| Left hemisphere | |||||
| Inferior parietal lobule (BA 7,40) | −30 | −55 | 43 | 6.35 | 1718 |
| Precuneus (BA 7) | −6 | −70 | 37 | 5.82 | 2905 |
| Middle frontal (BA 46) | −39 | 38 | 16 | 4.76 | 903 |
| Middle temporal gyrus (BA 21) | −61 | −29 | −8 | 4.73 | 85 |
| Medial PFC (BA 8) | −3 | 30 | 47 | 4.53 | 818‡ |
| Caudate | −11 | 5 | 8 | 4.32 | 204 |
| Middle frontal (BA 8) | −49 | 15 | 39 | 4.15 | 224 |
| Insula (BA 13) | −29 | 17 | 6 | 3.75 | 283 |
| Right hemisphere | |||||
| Inferior parietal lobule (BA 40) | 43 | −51 | 41 | 5.43 | 1537 |
| Caudate | 9 | 11 | 1 | 5.19 | 191 |
| Insula (BA 13) | 30 | 17 | −7 | 4.87 | 372 |
| Medial PFC (BA 32,10) | 5 | 35 | 13 | 3.89 | 818‡ |
| Middle frontal (BA 10) | 33 | 53 | 6 | 4.20 | 468 |
| Middle temporal gyrus (BA 21) | 55 | −37 | −5 | 3.82 | 110 |
| Interaction | |||||
| Controls > patients | |||||
| Left hemisphere | |||||
| Parahippocampal gyrus (BA 35) | −17 | −29 | −6 | 4.36 | 69 |
| Right hemisphere | |||||
| Medial frontal/frontal pole (BA 10) | 19 | 59 | 17 | 5.62 | 188 |
| Paracentral lobule (BA 31) | 2 | −21 | 42 | 3.89 | 71 |
| Superior frontal (BA 6) | 21 | 28 | 32 | 3.87 | 87 |
| Patients > controls | |||||
| Right hemisphere | |||||
| Thalamus | 17 | −30 | 5 | 3.60 | 54 |
BA = Brodmann area; PFC = prefrontal cortex.
↵* The cluster size represents the number of voxels. Talairach coordinates represent the peak voxel of each cluster where x, y, and z indicate the distance measured in millimetres from the anterior commissure in the sagittal, coronal and horizontal planes, respectively. All clusters of activation were significant at p < 0.005, uncorrected for multiple comparisons, with a minimum cluster size of 43 contiguous voxels, corresponding to a false-discovery rate of less than 5% across the whole brain as estimated by Monte Carlo simulation.
↵† The t value reported for the conjunction analysis corresponds to the lowest t value between the groups.
↵‡ These peak voxels belong to the same cluster of activation.