Demographic and clinical characteristics of participants with MCI and no depression history (MCI), MCI and a history of major depression (MCI-MD) and healthy controls
| Group; mean ± SD* | |||||
|---|---|---|---|---|---|
| Characteristic | MCI n = 30 | MCI-MD n = 36 | Control n = 22 | Statistic† | p value |
| Sex, female; no. (%)‡ | 11 (36.7) | 19 (52.8) | 14 (63.6) | 3.9 | 0.14 |
| Age, yr | 68.1 ± 8.4 | 64.6 ± 8.2 | 64.3 ± 8.7 | 1.9 | 0.16 |
| Education, yr | 14.3 ± 3.5 | 13.9 ± 3.6 | 13.5 ± 2.8 | 0.3 | 0.71 |
| Mini Mental State Examination | 28.0 ± 2.0§ | 28.5± 2.0 | 29.4 ± 0.9 | 4.1 | 0.019 |
| WTAR — Predicted IQ | 106.9 ± 9.2 | 108.2 ± 8.6 | 107.4 ± 7.3 | 1.8 | 0.84 |
| SOFAS | 75.4 ± 10.2 | 69.1 ± 9.9¶ | 82.3 ± 9.6 | 11.1 | < 0.001 |
| HAM-D | 3.4 ± 3.4 | 7.7 ± 4.6¶ | 1.9 ± 2.2 | 18.3 | < 0.001 |
| CIRS, total score | 5.2 ± 2.7 | 5.8 ± 3.4§ | 3.5 ± 2.0 | 4.2 | 0.019 |
| Vascular risk factors, no. (%)‡ | |||||
| Diabetes | 2 (6.7) | 6 (16.7) | 3 (13.6) | 1.6 | 0.45 |
| Hypertension | 15 (50.0) | 14 (38.9) | 5 (22.7) | 3.1 | 0.21 |
| Smoking history | 20 (66.7) | 21 (58.3) | 12 (54.5) | 1.3 | 0.53 |
| Cardiovascular disease | 4 (13.3) | 2 (5.5) | 0 (0.0) | 3.8 | 0.15 |
| Hypercholesterolemia | 10 (33.3) | 20 (55.5) | 7 (31.8) | 4.0 | 0.14 |
| Total | 1.8 ± 1.1 | 1.8 ± 1.0 | 1.4 ± 0.7 | 1.5 | 0.23 |
| Fazekas White Matter Ratings | |||||
| Periventricular white matter | 1.2 ± 0.8 | 1.5 ± 0.9 | 1.0 ± 1.0 | 2.7 | 0.07 |
| Deep white matter | 0.8 ± 0.7 | 1.2 ± 1.0§ | 0.6 ± 0.8 | 3.6 | 0.032 |
| Subcortical white matter | 0.7 ± 0.5 | 1.0 ± 0.9 | 0.6 ± 0.7 | 2.4 | 0.10 |
| Global rating | 0.9 ± 0.7 | 1.3 ± 1.0§ | 0.6 ± 0.7 | 4.7 | 0.012 |
CIRS = Cumulative Illness Rating Scale; HAM-D = Hamilton Rating Scale for Depression; MCI = mild cognitive impairment; MD = major depression; SD = standard deviation; SOFAS = Social and Occupational Functioning Assessment Scale; WTAR = Wechsler Test of Adult Reading.
↵* Unless otherwise indicated.
↵† Statistics represent 1-way analysis of variance with Scheffe post hoc test, unless otherwise stated.
↵‡ χ2 statistic.
↵§ Post hoc paired comparisons showed significant (p < 0.05) group difference compared with controls.
↵¶ Post hoc paired comparisons showed significant (p < 0.01) group difference compared with patients with MCI and controls.