Demographic, clinical and psychosocial characteristics of the groups
| Group; no. (%)* | |||||
|---|---|---|---|---|---|
| Characteristic | CSA+, n = 22 | CSA−, n = 82 | Control, n = 20 | Statistic | p value |
| Age, mean ± SD yr | 31.8 ± 6.2 | 28.1 ± 7.6 | 29.5 ± 8.8 | F2,120 = 2.12 | 0.12 |
| Menstrual cycle | χ22 = 0.42 | 0.80 | |||
| Follicular phase | 13 (59.1) | 47 (57.3) | 10 (50) | — | — |
| Luteal phase | 9 (40.9) | 35 (42.6) | 10 (50) | — | — |
| Comorbidities | |||||
| Depressive episode | 6 (27.2) | 13 (15.8) | — | χ21 = 1.35 | 0.24 |
| Bipolar disorder | 1 (4.5) | 11 (13.4) | — | χ21 = 1.16 | 0.28 |
| Posttraumatic stress disorder | 5 (22.7) | 7 (8.5) | — | χ21 = 2.98 | 0.08 |
| Other axis I disorder | 4 (18.1) | 8 (9.7) | — | χ21 = 1.53 | 0.21 |
| Medication | |||||
| Mood stabilizers | 10 (45.5) | 44 (53.7) | — | χ21 = 0.46 | 0.49 |
| Neuroleptics | 10 (45.5) | 48 (58.5) | — | χ21 = 1.21 | 0.27 |
| Antidepressants | 1 (4.5) | 7 (8.5) | — | χ21 = 0.38 | 0.53 |
| CTQ–CSA, mean ± SD | 18.31 ± 5.25 | 6.08 ± 2.52 | — | U = 98† | < 0.001 |
| BMI, mean ± SD | |||||
| Baseline | 22.8 ± 3.1 | 22.3 ± 3.5 | 23.7 ± 3.2 | F2,121 = 1.40 | 0.24 |
| 11 d | 23.7 ± 3.2 | 23.1 ± 3.7 | — | F2,121 = 0.43‡ | 0.65 |
| 18 d | 24.3 ± 3.5 | 23.9 ± 3.4 | — | F2,121 = 0.14‡ | 0.86 |
BMI = Body Mass Index; CSA+ = crack cocaine dependence with a history of childhood sexual abuse; CSA− = crack cocaine dependence without a history of childhood sexual abuse; CTQ = Childhood Trauma Questionnaire; SD = standard deviation.
↵* Unless otherwise indicated.
↵† U = Wilcoxon Mann Whitney test.
↵‡ Phase of menstrual cycle during first week of hospitalization.