MNI coordinates | ||||||
---|---|---|---|---|---|---|
Contrast | p value† | K | t | x | y | z |
Maltreatment < no maltreatment | ||||||
R hippocampus | 0.001 | 362 | 4.54 | 30 | −37 | −5 |
L hippocampus | 0.020 | 228 | 3.53 | −28 | −37 | −5 |
No maltreatment < maltreatment | ||||||
L OFC (front inf orb) | 0.024 | 177 | 3.84 | −51 | 35 | −8 |
R DMPFC | 0.025 | 71 | 3.69 | 15 | 69 | 18 |
Control > MDD | ||||||
L OFC (front inf orb) | 0.06 | 152 | 3.50 | −54 | 36 | −8 |
L DMPFC | 0.027 | 104 | 3.75 | −9 | 56 | 12 |
Control < MDD† | ||||||
Control maltreatment > control no maltreatment | ||||||
Control maltreatment > control no maltreatment | ||||||
Control no maltreatmen t > MDD no maltreatment | ||||||
R OFC (front mid or b) | 0.015 | 337 | 4.02 | 28 | 44 | −23 |
L OFC (front mid or b) | 0.06 | 38 | 3.49 | −48 | 48 | 9 |
L ACC. | 0.05 | 15 | 3.30 | −15 | 42 | 13 |
Control no maltreatmen t < MDD no maltreatment | ||||||
MDD maltreatment > M DD no maltreatment | ||||||
MDD maltreatment < M DD no maltreatment | ||||||
R hippocampus | 0.016 | 83 | 3.63 | 32 | −37 | 5 |
Control maltreatment < MDD maltreatment | ||||||
Control maltreatment > MDD maltreatment |
ACC = anterior cingulate cortex; DLPFC = dorsolateral prefrontal cortex; DMPFC = dorsomedial prefrontal cortex; FEW = family-wise error; K = number of significant voxels; L = left; MDD = major depressive disorder; MNI = Montreal Neurological Institute; OFC = orbitofrontal cortex; R = right.
↵* Regions of interest were the hippocampus, OFC, DMPFC, DLPFC and ACC. A threshold of p < 0.001, uncorrected, with a spatial extent threshold of 15 contiguous voxels was used to test group differences on a voxel level, and this was corrected for multiple voxel comparisons (cutoff value p < 0.05, FWE–corrected). No significant interaction was detected between childhood maltreatment and group (MDD, control).
↵† FWE–corrected.