Table 3

Results from the regression analysis^*

	Coefficients				Statistics

Brain region; factor	β	T	p value		R²	F	p value
Left hippocampus						F_total = 6.3	< 0.001
Diagnosis	−0.05	−0.47	0.64
Age	−0.15	−1.5	0.13		0.13	F_3,79 = 4.0	0.010
Sex	−0.18	−1.7	0.08
Maltreatment	−0.37	−3.4	0.001		0.113	F_1,78 = 11.6	< 0.001
Right hippocampus						F_total = 6.0	< 0.001
Diagnosis	−0.13	−1.2	0.23
Age	−0.002	−0.02	0.99		0.08	F_3,79 = 2.3	0.08
Sex	−0.18	−1.7	0.09
Maltreatment	−0.44	−4.0	< 0.001		0.154	F_1,78 = 15.7	< 0.001
Left DMPFC						F_total = 15.4	< 0.001
Diagnosis	0.33	3.7	< 0.001
Age	−0.55	−6.2	< 0.001		0.40	F_3,79 = 17.2	< 0.001
Sex	−0.18	−2.0	0.048
Maltreatment	0.24	2.5	0.013		0.046	F_1,78 = 6.4	0.013
Right DMPFC						F_total = 9.4	< 0.001
Diagnosis	0.14	1.4	0.16
Age	−0.52	−5.4	< 0.001		0.24	F_3,79 = 8.1	< 0.001
Sex	−0.16	−1.6	0.11
Maltreatment	0.33	3.2	0.002		0.089	F_1,78 = 10.3	0.002
Left OFC						F_total = 22.2	< 0.001
Diagnosis	0.27	3.2	0.002
Age	−0.60	−7.5	< 0.001		0.45	F_3,79 = 21.4	<0.001
Sex	−0.33	−4.1	< 0.001
Maltreatment	0.32	3.7	< 0.001		0.084	F_1,78 = 14.0	< 0.001
Right OFC						F_total = 9.7	< 0.001
Diagnosis	0.31	3.1	0.002
Age	−0.43	−4.3	< 0.001		0.33	F_2,79 = 12.8	< 0.001
Sex	−0.21	−2.1	0.043
Maltreatment	0.08	0.76	0.45		0.005	F_1,78 = 0.6	0.45

DMPFC = dorsomedial prefrontal cortex; OFC = orbitofrontal cortex.
↵* Results from the regression analysis with diagnosis, age and sex entered as independent variables in a first model and grey matter volumes as dependent variables. Childhood maltreatment was entered in a second step to see whether it would further influence variance in addition to the factors age, sex or diagnosis. Depicted are coefficients and statistics of change. A positive association between brain volume and diagnosis indicates smaller volumes in patients.